Gelin Xu1, Zhiming Zhou, Wusheng Zhu, Xiaobing Fan, Xinfeng Liu. 1. Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China. gelinxu@gmail.com
Abstract
OBJECTIVE: To investigate the relationship between plasma C-reactive protein (CRP) and the risk for cognitive deterioration and development of dementia in patients with mild cognitive impairment (MCI). METHODS: Elderly Chinese patients with suspected cognitive impairment were screened. A total of 168 patients who met the criteria for MCI were enrolled. Plasma CRP levels were measured at baseline. The global cognitive functions were assessed at baseline and during follow-up periodically with Mini-Mental State Examination (MMSE). All enrolled patients were followed and evaluated regularly for 2 years to determine if the patients developed dementia. RESULTS: Of the 168 patients with MCI diagnosed at baseline, 14 (8.3%) deceased, 13 (7.7%) lost to follow-up, and 58 (34.5%) developed dementia during follow-up. MMSE score of the enrolled patients declined significantly during follow-up (22.1 +/- 3.0 vs 18.6 +/- 5.5, P < 0.001). MMSE score was significantly lower for the patients with high CRP levels than that for those with low plasma CRP levels (-4.9 +/- 5.4 vs -3.2 +/- 4.2, P < 0.05). Patients with high plasma CRP level had an increased risk for dementia and vascular dementia as compared with patients with low level of plasma CRP (Log rank test, P < 0.05). CONCLUSION: High plasma CRP level was associated with accelerated cognitive decline and increased risk for dementia in patients with MCI.
OBJECTIVE: To investigate the relationship between plasma C-reactive protein (CRP) and the risk for cognitive deterioration and development of dementia in patients with mild cognitive impairment (MCI). METHODS: Elderly Chinese patients with suspected cognitive impairment were screened. A total of 168 patients who met the criteria for MCI were enrolled. Plasma CRP levels were measured at baseline. The global cognitive functions were assessed at baseline and during follow-up periodically with Mini-Mental State Examination (MMSE). All enrolled patients were followed and evaluated regularly for 2 years to determine if the patients developed dementia. RESULTS: Of the 168 patients with MCI diagnosed at baseline, 14 (8.3%) deceased, 13 (7.7%) lost to follow-up, and 58 (34.5%) developed dementia during follow-up. MMSE score of the enrolled patients declined significantly during follow-up (22.1 +/- 3.0 vs 18.6 +/- 5.5, P < 0.001). MMSE score was significantly lower for the patients with high CRP levels than that for those with low plasma CRP levels (-4.9 +/- 5.4 vs -3.2 +/- 4.2, P < 0.05). Patients with high plasma CRP level had an increased risk for dementia and vascular dementia as compared with patients with low level of plasma CRP (Log rank test, P < 0.05). CONCLUSION: High plasma CRP level was associated with accelerated cognitive decline and increased risk for dementia in patients with MCI.
Authors: Rebecca C Stebbins; Jessie K Edwards; Brenda L Plassman; Y Claire Yang; Grace A Noppert; Mary Haan; Allison E Aiello Journal: Psychoneuroendocrinology Date: 2021-09-15 Impact factor: 4.905
Authors: Emiliano Peña-Altamira; Sabrina Petralla; Francesca Massenzio; Marco Virgili; Maria L Bolognesi; Barbara Monti Journal: Front Aging Neurosci Date: 2017-06-07 Impact factor: 5.750