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Literature DB >> 19416727

The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.

Corina Tudor¹, Francesco P Marchese, Edward Hitti, Anna Aubareda, Lesley Rawlinson, Matthias Gaestel, Perry J Blackshear, Andrew R Clark, Jeremy Saklatvala, Jonathan L E Dean.

Abstract

p38 mitogen-activated protein kinase (MAPK) stabilises pro-inflammatory mediator mRNAs by inhibiting AU-rich element (ARE)-mediated decay. We show that in bone-marrow derived murine macrophages tristetraprolin (TTP) is necessary for the p38 MAPK-sensitive decay of several pro-inflammatory mRNAs, including cyclooxygenase-2 and the novel targets interleukin (IL)-6, and IL-1alpha. TTP(-/-) macrophages also strongly overexpress IL-10, an anti-inflammatory cytokine that constrains the production of the IL-6 despite its disregulation at the post-transcriptional level. TTP directly controls IL-10 mRNA stability, which is increased and insensitive to inhibition of p38 MAPK in TTP(-/-) macrophages. Furthermore, TTP enhances deadenylation of an IL-10 3'-untranslated region RNA in vitro.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19416727 PMCID： PMC4798241 DOI： 10.1016/j.febslet.2009.04.039

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

47 in total

1. Heterogeneity in control of mRNA stability by AU-rich elements.

Authors: Julie Tebo; Sandy Der; Mathias Frevel; Khalid S A Khabar; Bryan R G Williams; Thomas A Hamilton
Journal: J Biol Chem Date: 2003-01-28 Impact factor: 5.157

2. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.

Authors: M Lasa; K R Mahtani; A Finch; G Brewer; J Saklatvala; A R Clark
Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

3. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

Authors: A D Foey; S L Parry; L M Williams; M Feldmann; B M Foxwell; F M Brennan
Journal: J Immunol Date: 1998-01-15 Impact factor: 5.422

4. Alternate COX-2 transcripts are differentially regulated: implications for post-transcriptional control.

Authors: R Newton; J Seybold; S F Liu; P J Barnes
Journal: Biochem Biophys Res Commun Date: 1997-05-08 Impact factor: 3.575

5. Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1).

Authors: Gareth Sully; Jonathan L E Dean; Robin Wait; Lesley Rawlinson; Tomas Santalucia; Jeremy Saklatvala; Andrew R Clark
Journal: Biochem J Date: 2004-02-01 Impact factor: 3.857

6. RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein.

Authors: Mark T Worthington; Jared W Pelo; Muhammadreza A Sachedina; Joan L Applegate; Kristen O Arseneau; Theresa T Pizarro
Journal: J Biol Chem Date: 2002-09-24 Impact factor: 5.157

7. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.

Authors: Wi S Lai; Elizabeth A Kennington; Perry J Blackshear
Journal: Mol Cell Biol Date: 2003-06 Impact factor: 4.272

8. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.

Authors: G A Taylor; E Carballo; D M Lee; W S Lai; M J Thompson; D D Patel; D I Schenkman; G S Gilkeson; H E Broxmeyer; B F Haynes; P J Blackshear
Journal: Immunity Date: 1996-05 Impact factor: 31.745

9. p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts.

Authors: Mathias A E Frevel; Tala Bakheet; Aristobolo M Silva; John G Hissong; Khalid S A Khabar; Bryan R G Williams
Journal: Mol Cell Biol Date: 2003-01 Impact factor: 4.272

10. Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.

Authors: Kate A Alford; Sarah Glennie; Bryony R Turrell; Lesley Rawlinson; Jeremy Saklatvala; Jonathan L E Dean
Journal: J Biol Chem Date: 2007-01-03 Impact factor: 5.157

51 in total

1. Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.

Authors: Ian M Kaplan; Sebastien Morisot; Diane Heiser; Wen-Chih Cheng; Min Jung Kim; Curt I Civin
Journal: J Immunol Date: 2011-01-26 Impact factor: 5.422

8. MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection.

Authors: Katharina Köther; Carolin Nordhoff; Dörthe Masemann; Georg Varga; Jay H Bream; Matthias Gaestel; Viktor Wixler; Stephan Ludwig
Journal: FASEB J Date: 2014-06-16 Impact factor: 5.191

Review 9. Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.

Authors: Seth A Brooks; Perry J Blackshear
Journal: Biochim Biophys Acta Date: 2013-02-18

Review 10. Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.

Authors: Khalid S A Khabar
Journal: Cell Mol Life Sci Date: 2010-05-22 Impact factor: 9.261