Literature DB >> 19414313

High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer.

Satoshi Ohno1, Yumiko Ohno, Nobutaka Suzuki, Gen-Ichiro Soma, Masaki Inoue.   

Abstract

Vitamin C (ascorbic acid, ascorbate) has a controversial history in cancer treatment. Emerging evidence indicates that ascorbate in cancer treatment deserves re-examination. As research results concerning ascorbate pharmacokinetics and its mechanisms of action against tumor cells have been published, and as evidence from case studies has continued to mount that ascorbate therapy could be effective if the right protocols were used, interest among physicians and scientists has increased. In this review, high-dose vitamin C therapy in cancer treatment is re-evaluated.

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Year:  2009        PMID： 19414313

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  47 in total

1.  AGO Recommendations for Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer. Update 2011.

Authors:  Christoph Thomssen; Anton Scharl; Nadia Harbeck
Journal:  Breast Care (Basel)       Date:  2011-08-30       Impact factor: 2.860

Review 2.  The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Authors:  Anthony R Cyr; Frederick E Domann
Journal:  Antioxid Redox Signal       Date:  2011-02-05       Impact factor: 8.401

3.  The Xc- inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism.

Authors:  Zijie Zheng; Ganhua Luo; Xinchong Shi; Yali Long; Wanqing Shen; Zhoulei Li; Xiangsong Zhang
Journal:  Cell Oncol (Dordr)       Date:  2019-10-15       Impact factor: 6.730

Review 4.  A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.

Authors:  Ines Batinic-Haberle; Zrinka Rajic; Ludmil Benov
Journal:  Anticancer Agents Med Chem       Date:  2011-05-01       Impact factor: 2.505

5.  Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

Authors:  Satya S Pathi; Ping Lei; Sandeep Sreevalsan; Gayathri Chadalapaka; Indira Jutooru; Stephen Safe
Journal:  Nutr Cancer       Date:  2011-09-15       Impact factor: 2.900

6.  Vitamin C induces apoptosis in AGS cells via production of ROS of mitochondria.

Authors:  Jae Young Lim; Donghyun Kim; Bok Ran Kim; Jin Su Jun; Jung Sook Yeom; Ji Sook Park; Ji-Hyun Seo; Chan Hoo Park; Hyang Ok Woo; Hee-Shang Youn; Seung-Chul Baik; Woo-Kon Lee; Myung-Je Cho; Kwang-Ho Rhee
Journal:  Oncol Lett       Date:  2016-09-29       Impact factor: 2.967

7.  Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials for Measurements of Pharmacological Ascorbate.

Authors:  Michael S Petronek; Brett A Wagner; Nancy J Hollenbeck; Joseph M Caster; Douglas R Spitz; Joseph J Cullen; Garry R Buettner; Bryan G Allen
Journal:  Radiat Res       Date:  2019-04-30       Impact factor: 2.841

8.  Ascorbic acid kills Epstein-Barr virus positive Burkitt lymphoma cells and Epstein-Barr virus transformed B-cells in vitro, but not in vivo.

Authors:  Amber N Shatzer; Michael Graham Espey; Mayra Chavez; Hongbin Tu; Mark Levine; Jeffrey I Cohen
Journal:  Leuk Lymphoma       Date:  2012-11-15

9.  The prospects of vitamin C in cancer therapy.

Authors:  Wang-Jae Lee
Journal:  Immune Netw       Date:  2009-10-30       Impact factor: 6.303

10.  Vitamin C in synergism with cisplatin induces cell death in cervical cancer cells through altered redox cycling and p53 upregulation.

Authors:  Ankita Leekha; Bahadur S Gurjar; Aakriti Tyagi; Moshahid A Rizvi; Anita K Verma
Journal:  J Cancer Res Clin Oncol       Date:  2016-09-09       Impact factor: 4.553
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