Literature DB >> 19408268

Total synthesis and stereochemical assignment of micrococcin P1.

David Lefranc1, Marco A Ciufolini.   

Abstract

Fifty years after the discovery of the thiopeptide antibiotic micrococcin P1, the constitutional and stereochemical uncertainties concerning its structure have been lifted with its total synthesis and absolute stereochemical assignment (see picture).

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Year:  2009        PMID： 19408268     DOI： 10.1002/anie.200900621

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  15 in total

1.  Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.

Authors:  Albert A Bowers; Michael G Acker; Alexander Koglin; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

Review 2.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

Review 3.  How thiostrepton was made in the laboratory.

Authors:  K C Nicolaou
Journal:  Angew Chem Int Ed Engl       Date:  2012-12-03       Impact factor: 15.336

Review 4.  Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

Authors:  Christopher T Walsh; Michael G Acker; Albert A Bowers
Journal:  J Biol Chem       Date:  2010-06-03       Impact factor: 5.157

5.  Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases.

Authors:  Aleksandra Mikolajka; Hanqing Liu; Yuanwei Chen; Agata L Starosta; Viter Márquez; Marina Ivanova; Barry S Cooperman; Daniel N Wilson
Journal:  Chem Biol       Date:  2011-05-27

Review 6.  Antibacterials from the sea.

Authors:  Chambers C Hughes; William Fenical
Journal:  Chemistry       Date:  2010-11-08       Impact factor: 5.236

7.  Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.

Authors:  Travis S Young; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-25       Impact factor: 11.205

8.  Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

Authors:  Michael G Acker; Albert A Bowers; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

9.  Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.

Authors:  Albert A Bowers; Christopher T Walsh; Michael G Acker
Journal:  J Am Chem Soc       Date:  2010-09-08       Impact factor: 15.419

10.  Total synthesis and complete structural assignment of thiocillin I.

Authors:  Virender S Aulakh; Marco A Ciufolini
Journal:  J Am Chem Soc       Date:  2011-03-29       Impact factor: 15.419
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