BACKGROUND: Cognitive impairment in schizophrenia-spectrum disorders is highly prevalent and notably influences functional outcomes. AIMS: To characterise the cognitive effectiveness of second-generation antipsychotic drugs. METHOD:One hundred consecutive and previously unmedicated patients with first-episode schizophrenia-spectrum disorders were admitted. Seventy-seven completed baseline, 1-month and 6-month psychopathological and neuropsychological assessments. Patients were randomised to risperidone or olanzapine treatment. Four final treatment allocation groups were defined since patients continued treatment in their normal setting: risperidone, olanzapine, mixed and no-antipsychotic groups. RESULTS: There were no differences in cognitive effectiveness between the four treatment groups. Reliable change index methods demonstrated that nearly a half of patients showed an improvement in Global Cognitive Score at the 6-month assessment. Improvement on the neuropsychological tests ranged from 17 to 54%. A strong predictor of cognitive response was poor performance on baseline neuropsychological tests; response was moderately influenced by a low premorbid scholastic performance and IQ. CONCLUSIONS:Cognitive improvement related to second-generation antipsychotic drugs appeared within the first 4 weeks of treatment and persisted at 6 months irrespective of treatment group. Greater cognitive dysfunction at baseline and lower premorbid cognitive background predicted cognitive improvement in our sample.
RCT Entities:
BACKGROUND:Cognitive impairment in schizophrenia-spectrum disorders is highly prevalent and notably influences functional outcomes. AIMS: To characterise the cognitive effectiveness of second-generation antipsychotic drugs. METHOD: One hundred consecutive and previously unmedicated patients with first-episode schizophrenia-spectrum disorders were admitted. Seventy-seven completed baseline, 1-month and 6-month psychopathological and neuropsychological assessments. Patients were randomised to risperidone or olanzapine treatment. Four final treatment allocation groups were defined since patients continued treatment in their normal setting: risperidone, olanzapine, mixed and no-antipsychotic groups. RESULTS: There were no differences in cognitive effectiveness between the four treatment groups. Reliable change index methods demonstrated that nearly a half of patients showed an improvement in Global Cognitive Score at the 6-month assessment. Improvement on the neuropsychological tests ranged from 17 to 54%. A strong predictor of cognitive response was poor performance on baseline neuropsychological tests; response was moderately influenced by a low premorbid scholastic performance and IQ. CONCLUSIONS: Cognitive improvement related to second-generation antipsychotic drugs appeared within the first 4 weeks of treatment and persisted at 6 months irrespective of treatment group. Greater cognitive dysfunction at baseline and lower premorbid cognitive background predicted cognitive improvement in our sample.
Authors: Maria S Campos; Elena Garcia-Jalon; James K Gilleen; Anthony S David; Victor M D Peralta; Manuel J Cuesta Journal: Schizophr Bull Date: 2010-10-25 Impact factor: 9.306
Authors: Salma R I Ribeiz; Débora P Bassitt; Jony A Arrais; Renata Avila; David C Steffens; Cássio M C Bottino Journal: CNS Drugs Date: 2010-04 Impact factor: 5.749
Authors: Manuel J Cuesta; Ana M Sánchez-Torres; Elena García de Jalón; Maria S Campos; Berta Ibáñez; Lucía Moreno-Izco; Víctor Peralta Journal: Schizophr Bull Date: 2013-09-26 Impact factor: 9.306
Authors: Rosa Ayesa-Arriola; Jose Manuel Rodríguez-Sánchez; Rocío Pérez-Iglesias; Roberto Roiz-Santiáñez; Obdulia Martínez-García; Jose Sánchez-Moreno; Rafael Tabarés-Seisdedos; Jose L Vázquez-Barquero; Benedicto Crespo-Facorro Journal: Psychopharmacology (Berl) Date: 2013-03-02 Impact factor: 4.530
Authors: A M Sánchez-Torres; L Moreno-Izco; R Lorente-Omeñaca; B Cabrera; A Lobo; A M González-Pinto; J Merchán-Naranjo; I Corripio; E Vieta; E de la Serna; A Butjosa; F Contreras; S Sarró; G Mezquida; M Ribeiro; M Bernardo; M J Cuesta Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-11-21 Impact factor: 5.270
Authors: G Désaméricq; F Schurhoff; A Meary; A Szöke; I Macquin-Mavier; A C Bachoud-Lévi; P Maison Journal: Eur J Clin Pharmacol Date: 2013-10-22 Impact factor: 2.953