BACKGROUND: Recent studies show that adverse life events have a significantly greater impact on depression onset for those with the s/s allele of the genotype for the 5-HT gene-linked promoter region. Research in genes related to risk of depression leads to the question of how this information is received by individuals. AIMS: To investigate factors related to the response to receiving one's own serotonin transporter genotype results. METHOD: Predictors of the impact of receiving individual genotype data were assessed in 128 participants in a study of gene-environment interaction in depression onset. RESULTS: Two-thirds decided to learn their individual genotype results (receivers) and prior to disclosure this decision was associated with a perception of greater benefit from receipt of the information (P=0.001). Receivers completing the 2-week (n=76) and 3-month follow-up (n=78) generally reported feeling pleased with the information and having had a more positive experience than distress. However, distress was related to genotype, with those with the s/s allele being most affected. CONCLUSIONS: There was high interest in, and satisfaction with, learning about one's serotonin transporter genotype. Participants appeared to understand that the gene conferred susceptibility to depression rather than a direct causal effect.
BACKGROUND: Recent studies show that adverse life events have a significantly greater impact on depression onset for those with the s/s allele of the genotype for the 5-HT gene-linked promoter region. Research in genes related to risk of depression leads to the question of how this information is received by individuals. AIMS: To investigate factors related to the response to receiving one's own serotonin transporter genotype results. METHOD: Predictors of the impact of receiving individual genotype data were assessed in 128 participants in a study of gene-environment interaction in depression onset. RESULTS: Two-thirds decided to learn their individual genotype results (receivers) and prior to disclosure this decision was associated with a perception of greater benefit from receipt of the information (P=0.001). Receivers completing the 2-week (n=76) and 3-month follow-up (n=78) generally reported feeling pleased with the information and having had a more positive experience than distress. However, distress was related to genotype, with those with the s/s allele being most affected. CONCLUSIONS: There was high interest in, and satisfaction with, learning about one's serotonin transporter genotype. Participants appeared to understand that the gene conferred susceptibility to depression rather than a direct causal effect.
Authors: Sarah Hohmann; Nicoletta Adamo; Benjamin B Lahey; Stephen V Faraone; Tobias Banaschewski Journal: Eur Child Adolesc Psychiatry Date: 2015-04-08 Impact factor: 4.785
Authors: Gabriel Lázaro-Muñoz; Maya Sabatello; Laura Huckins; Holly Peay; Franziska Degenhardt; Bettina Meiser; Todd Lencz; Takahiro Soda; Anna Docherty; David Crepaz-Keay; Jehannine Austin; Roseann E Peterson; Lea K Davis Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2019-05-23 Impact factor: 3.568
Authors: Eric A Dedert; Eric B Elbogen; Michael A Hauser; Jeff S Hertzberg; Sarah M Wilson; Michelle F Dennis; Patrick S Calhoun; Angela C Kirby; Jean C Beckham Journal: Genet Test Mol Biomarkers Date: 2012-08-14