Literature DB >> 19402864

DNAzymes and their therapeutic possibilities.

C W S Chan1, L M Khachigian.   

Abstract

Our increasing understanding of the regulatory mechanisms involved in the pathogenesis of disease is opening up opportunities for therapeutic intervention. To tackle the unmet disease burden, the last decade has seen the emergence of gene-targeting small-molecule nucleic acid-based strategies, such as antisense oligodeoxynucleotides, ribozymes, small interfering RNA and DNAzymes. DNAzymes represent promising candidates for drug therapy in a wide range of diseases, such as cancer and cardiovascular disorders. This brief review will discuss recent developments in DNAzymes and their therapeutic potential.

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Year:  2009        PMID： 19402864     DOI： 10.1111/j.1445-5994.2009.01799.x

Source DB:  PubMed          Journal:  Intern Med J        ISSN： 1444-0903            Impact factor:   2.048


  10 in total

Review 1.  MicroRNAs (miRNAs) in cancer invasion and metastasis: therapeutic approaches based on metastasis-related miRNAs.

Authors:  Achim Aigner
Journal:  J Mol Med (Berl)       Date:  2011-01-14       Impact factor: 4.599

2.  Activation and deactivation of DNAzyme and antisense function with light for the photochemical regulation of gene expression in mammalian cells.

Authors:  Douglas D Young; Mark O Lively; Alexander Deiters
Journal:  J Am Chem Soc       Date:  2010-05-05       Impact factor: 15.419

3.  Inhibition of HIV-1 Integrase gene expression by 10-23 DNAzyme.

Authors:  Nirpendra Singh; Atul Ranjan; Souvik Sur; Ramesh Chandra; Vibha Tandon
Journal:  J Biosci       Date:  2012-07       Impact factor: 1.826

Review 4.  Translational control of gene function through optically regulated nucleic acids.

Authors:  Kristie E Darrah; Alexander Deiters
Journal:  Chem Soc Rev       Date:  2021-11-29       Impact factor: 54.564

5.  Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme.

Authors:  Cecilia W S Chan; Warren Kaplan; Christopher R Parish; Levon M Khachigian
Journal:  PLoS One       Date:  2012-07-17       Impact factor: 3.240

6.  Inhibiting the HIV integration process: past, present, and the future.

Authors:  Roberto Di Santo
Journal:  J Med Chem       Date:  2013-09-25       Impact factor: 7.446

7.  Double-stem Hairpin Probe and Ultrasensitive Colorimetric Detection of Cancer-related Nucleic Acids.

Authors:  Jianguo Xu; Hongling Li; Zai-Sheng Wu; Jun Qian; Chang Xue; Lee Jia
Journal:  Theranostics       Date:  2016-01-01       Impact factor: 11.556

8.  Novel Chemically-modified DNAzyme targeting Integrin alpha-4 RNA transcript as a potential molecule to reduce inflammation in multiple sclerosis.

Authors:  Madhuri Chakravarthy; May T Aung-Htut; Bao T Le; Rakesh N Veedu
Journal:  Sci Rep       Date:  2017-05-09       Impact factor: 4.379

Review 9.  Tetrahedral DNA nanostructures as drug delivery and bioimaging platforms in cancer therapy.

Authors:  Ratchanee Duangrat; Anuttara Udomprasert; Thaned Kangsamaksin
Journal:  Cancer Sci       Date:  2020-07-20       Impact factor: 6.716

Review 10.  Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders.

Authors:  Pranav Shah; Manisha Lalan; Kalyani Barve
Journal:  Front Pharmacol       Date:  2022-08-30       Impact factor: 5.988
  10 in total

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