OBJECTIVE: To determine the antibacterial properties of Quinine dihydrochloride and its MIC. MATERIAL AND METHODS: A Quasi-Experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi from July 2006 to November 2006. Two hundred samples of pus, blood, sputum and ascitic fluid, from hospitalized adult patients from Medicine ward (W-7) having different Bacterial infections were studied. Proforma was filled to document the demographic details. Samples were collected from different sites, isolated, identified and checked for antimicrobial susceptibility of quinine dihydrochloride by standard methods. RESULTS: Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Salmonella typhi were inhibited at MIC of 125 g/ml. Streptococcus pyogenes was inhibited at MIC of 31.25 g/ml of quinine dihydrochloride (Dilution ranges from 31.25 g/ml to 1000 g/ml). CONCLUSION: The concomitant antimalarial and antibacterial action of Quinine dihydrochloride may be beneficial in developing countries adding to cost effectiveness of treatment provided to patients belonging to low socioeconomic group.
OBJECTIVE: To determine the antibacterial properties of Quinine dihydrochloride and its MIC. MATERIAL AND METHODS: A Quasi-Experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi from July 2006 to November 2006. Two hundred samples of pus, blood, sputum and ascitic fluid, from hospitalized adult patients from Medicine ward (W-7) having different Bacterial infections were studied. Proforma was filled to document the demographic details. Samples were collected from different sites, isolated, identified and checked for antimicrobial susceptibility of quinine dihydrochloride by standard methods. RESULTS:Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Salmonella typhi were inhibited at MIC of 125 g/ml. Streptococcus pyogenes was inhibited at MIC of 31.25 g/ml of quinine dihydrochloride (Dilution ranges from 31.25 g/ml to 1000 g/ml). CONCLUSION: The concomitant antimalarial and antibacterial action of Quinine dihydrochloride may be beneficial in developing countries adding to cost effectiveness of treatment provided to patients belonging to low socioeconomic group.
Authors: Leon G Leanse; Pu-Ting Dong; Xueping S Goh; Min Lu; Ji-Xin Cheng; David C Hooper; Tianhong Dai Journal: J Infect Dis Date: 2020-02-03 Impact factor: 5.226
Authors: Gulim K Mukusheva; Aigerym R Zhasymbekova; Roza B Seidakhmetova; Oralgazy A Nurkenov; Ekaterina A Akishina; Sergey K Petkevich; Evgenij A Dikusar; Vladimir I Potkin Journal: Molecules Date: 2022-05-27 Impact factor: 4.927
Authors: Olajumoke A Olateju; Chinedum P Babalola; Olujide O Olubiyi; Olayinka A Kotila; David A Kwasi; Anderson O Oaikhena; Iruka N Okeke Journal: Front Microbiol Date: 2021-06-02 Impact factor: 5.640