AIMS: The aim of this study involves the early identification, among apparently healthy individuals, of those at high risk for sudden cardiac death. We tested the hypothesis that individuals who respond to mild mental stress in preparation for exercise test with the largest heart rate increases might be at highest risk. METHODS AND RESULTS: Data from 7746 civil servants participating in the Paris Prospective Study I, followed-up for 23 years, allowed to compare heart rate changes between rest and mild mental stress (preparation prior to an exercise test) between subjects who suffered sudden cardiac death (n = 81), non-sudden (n = 129) coronary death, or death from any cause (n = 1306). The mean heart rate increase during mild mental stress was 8.9 +/- 10.8 b.p.m. Risk of sudden cardiac death increased progressively with heart rate increase during mental stress and the relative risk of the third vs. the first tertile was 2.09 (95% confidence interval, 1.13-3.86) after adjustment for confounders. This relationship was not observed for non-sudden coronary death. CONCLUSION: An important heart rate increase produced by a mild mental stress predicts long-term risk for sudden cardiac death. Heart rate changes before an exercise test may provide a simple tool for risk stratification.
AIMS: The aim of this study involves the early identification, among apparently healthy individuals, of those at high risk for sudden cardiac death. We tested the hypothesis that individuals who respond to mild mental stress in preparation for exercise test with the largest heart rate increases might be at highest risk. METHODS AND RESULTS: Data from 7746 civil servants participating in the Paris Prospective Study I, followed-up for 23 years, allowed to compare heart rate changes between rest and mild mental stress (preparation prior to an exercise test) between subjects who suffered sudden cardiac death (n = 81), non-sudden (n = 129) coronary death, or death from any cause (n = 1306). The mean heart rate increase during mild mental stress was 8.9 +/- 10.8 b.p.m. Risk of sudden cardiac death increased progressively with heart rate increase during mental stress and the relative risk of the third vs. the first tertile was 2.09 (95% confidence interval, 1.13-3.86) after adjustment for confounders. This relationship was not observed for non-sudden coronary death. CONCLUSION: An important heart rate increase produced by a mild mental stress predicts long-term risk for sudden cardiac death. Heart rate changes before an exercise test may provide a simple tool for risk stratification.
Authors: Glenn I Fishman; Sumeet S Chugh; John P Dimarco; Christine M Albert; Mark E Anderson; Robert O Bonow; Alfred E Buxton; Peng-Sheng Chen; Mark Estes; Xavier Jouven; Raymond Kwong; David A Lathrop; Alice M Mascette; Jeanne M Nerbonne; Brian O'Rourke; Richard L Page; Dan M Roden; David S Rosenbaum; Nona Sotoodehnia; Natalia A Trayanova; Zhi-Jie Zheng Journal: Circulation Date: 2010-11-30 Impact factor: 29.690
Authors: Elsayed Z Soliman; Ronald J Prineas; L Douglas Case; Gregory Russell; Wayne Rosamond; Thomas Rea; Nona Sotoodehnia; Wendy S Post; David Siscovick; Bruce M Psaty; Gregory L Burke Journal: Heart Date: 2011-07-20 Impact factor: 5.994
Authors: F Z Marques; N Eikelis; R G Bayles; E A Lambert; N E Straznicky; D Hering; M D Esler; G A Head; D A Barton; M P Schlaich; G W Lambert Journal: Mol Psychiatry Date: 2016-04-05 Impact factor: 15.992