CONTEXT: Body weight has been associated with bone mass and bone size through shared genetic determination and environmental influences. Whereas lean mass exerts a positive influence on bone size, the relationship between fat and bone remains unclear. OBJECTIVE: The objective of the present study was to investigate the individual influence of fat mass and lean mass on volumetric bone density and size in young healthy male siblings at age of peak bone mass. DESIGN: This was a cross-sectional, population-based sibling pair study. PARTICIPANTS: A total of 677 men (25-45 yr) were included in this study with 296 independent pairs of brothers. MAIN OUTCOME MEASURES: Areal and volumetric bone parameters were determined using dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). Body composition was determined by DXA. Sex steroids, leptin, and adiponectin were determined by immunoassay. RESULTS: Total and regional fat mass were found to be inversely associated with areal bone mass and bone size, independent from lean mass (radius periosteal circumference beta: -0.29 +/- 0.04; P < 0.001). Lean mass was positively associated with bone size but inversely with cortical density at both tibia and radius (P < 0.01). The negative association between total fat mass and bone size was independent from sex steroid concentrations. Leptin but not adiponectin was inversely associated with bone size, but this was no longer significant after adjustment for body fat. CONCLUSIONS: Increased fat mass is associated with smaller bone size, challenging the view of a high bone mass index as a protective factor for osteoporosis, whereas lean mass was a consistent positive determinant of bone size.
CONTEXT: Body weight has been associated with bone mass and bone size through shared genetic determination and environmental influences. Whereas lean mass exerts a positive influence on bone size, the relationship between fat and bone remains unclear. OBJECTIVE: The objective of the present study was to investigate the individual influence of fat mass and lean mass on volumetric bone density and size in young healthy male siblings at age of peak bone mass. DESIGN: This was a cross-sectional, population-based sibling pair study. PARTICIPANTS: A total of 677 men (25-45 yr) were included in this study with 296 independent pairs of brothers. MAIN OUTCOME MEASURES: Areal and volumetric bone parameters were determined using dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). Body composition was determined by DXA. Sex steroids, leptin, and adiponectin were determined by immunoassay. RESULTS: Total and regional fat mass were found to be inversely associated with areal bone mass and bone size, independent from lean mass (radius periosteal circumference beta: -0.29 +/- 0.04; P < 0.001). Lean mass was positively associated with bone size but inversely with cortical density at both tibia and radius (P < 0.01). The negative association between total fat mass and bone size was independent from sex steroid concentrations. Leptin but not adiponectin was inversely associated with bone size, but this was no longer significant after adjustment for body fat. CONCLUSIONS: Increased fat mass is associated with smaller bone size, challenging the view of a high bone mass index as a protective factor for osteoporosis, whereas lean mass was a consistent positive determinant of bone size.
Authors: Howard E Wey; Teresa L Binkley; Tianna M Beare; Christine L Wey; Bonny L Specker Journal: J Clin Endocrinol Metab Date: 2010-10-06 Impact factor: 5.958
Authors: S Verschueren; E Gielen; T W O'Neill; S R Pye; J E Adams; K A Ward; F C Wu; P Szulc; M Laurent; F Claessens; D Vanderschueren; S Boonen Journal: Osteoporos Int Date: 2012-07-10 Impact factor: 4.507
Authors: Natalie A Glass; James C Torner; Elena M Letuchy; Trudy L Burns; Kathleen F Janz; Julie M Eichenberger Gilmore; Janet A Schlechte; Steven M Levy Journal: J Bone Miner Res Date: 2017-11-27 Impact factor: 6.741
Authors: Didier Chalhoub; Robert Boudreau; Susan Greenspan; Anne B Newman; Joseph Zmuda; Andrew W Frank-Wilson; Nayana Nagaraj; Andrew R Hoffman; Nancy E Lane; Marcia L Stefanick; Elizabeth Barrett-Connor; Tien Dam; Peggy M Cawthon; Eric S Orwoll; Jane A Cauley Journal: J Bone Miner Res Date: 2018-06-12 Impact factor: 6.741
Authors: Carlos Alberto Soares da Costa; Aluana Santana Carlos; Gabrielle de Paula Lopes Gonzalez; Rejane Pontes Gaspar Reis; Mariana Dos Santos Ribeiro; Aline de Sousa Dos Santos; Alexandra Maria Vieira Monteiro; Egberto Gaspar de Moura; Celly Cristina Alves do Nascimento-Saba Journal: Eur J Nutr Date: 2011-05-26 Impact factor: 5.614
Authors: Lina E Aguirre; Georgia Colleluori; Richard Dorin; David Robbins; Rui Chen; Bryan Jiang; Clifford Qualls; Dennis T Villareal; Reina Armamento-Villareal Journal: Calcif Tissue Int Date: 2017-08-30 Impact factor: 4.333