Literature DB >> 19400033

Biochemical and biophysical studies on cytochrome c oxidase. XIII. Effect of cholate on the enzymic activity.

K J Van Buuren1, B F Van Gelder.   

Abstract

(1) Cholate is a mixed-type inhibitor of the enzymic activity of cytochrome c oxidase. The rate equations for mixed-type inhibition of the enzyme have been derived, based on Minnaert's Mechanism IV (1961, Biochim. Biophys. Acta 50, 23-34). The Ki of cholate for the free enzyme (E) and for the complexes of the enzyme with cytochrome c (ES and EP) was determined, being 125 and 190 microM, respectively. (2) Comparison of the properties of cholate and the intrinsic inhibitor of cytochrome c oxidase (Van Buuren et al. (1971) Biochim. Biophys. Acta 243, 468-480) with respect to their type of inhibition and their affinity for enzyme, reveals that they are identical.

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Year:  1974        PMID： 19400033     DOI： 10.1016/0005-2728(74)90005-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Properties of protease-treated cytochrome c oxidase from beef heart.

Authors:  J C Boonman; G G van Beek; A O Muijsers; B F van Gelder
Journal:  Mol Cell Biochem       Date:  1979-08-15       Impact factor: 3.396

Review 2.  Role of conformational change and K-path ligands in controlling cytochrome c oxidase activity.

Authors:  Jian Liu; Carrie Hiser; Shelagh Ferguson-Miller
Journal:  Biochem Soc Trans       Date:  2017-08-24       Impact factor: 5.407

3.  Structural basis of mammalian complex IV inhibition by steroids.

Authors:  Justin M Di Trani; Agnes Moe; Daniel Riepl; Patricia Saura; Ville R I Kaila; Peter Brzezinski; John L Rubinstein
Journal:  Proc Natl Acad Sci U S A       Date:  2022-07-19       Impact factor: 12.779

4.  A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase.

Authors:  Carrie Hiser; Leann Buhrow; Jian Liu; Leslie Kuhn; Shelagh Ferguson-Miller
Journal:  Biochemistry       Date:  2013-02-12       Impact factor: 3.162

5.  A conserved steroid binding site in cytochrome C oxidase.

Authors:  Ling Qin; Denise A Mills; Leann Buhrow; Carrie Hiser; Shelagh Ferguson-Miller
Journal:  Biochemistry       Date:  2008-08-30       Impact factor: 3.162

6.  Monomeric structure of an active form of bovine cytochrome c oxidase.

Authors:  Kyoko Shinzawa-Itoh; Takashi Sugimura; Tomonori Misaki; Yoshiki Tadehara; Shogo Yamamoto; Makoto Hanada; Naomine Yano; Tetsuya Nakagawa; Shigefumi Uene; Takara Yamada; Hiroshi Aoyama; Eiki Yamashita; Tomitake Tsukihara; Shinya Yoshikawa; Kazumasa Muramoto
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-18       Impact factor: 11.205
  6 in total

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