Literature DB >> 19398146

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.

Osama M Ahmed1, Mahmoud A Mohamed, Rasha R Ahmed, Sayed A Ahmed.   

Abstract

Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.

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Year:  2009        PMID： 19398146     DOI： 10.1016/j.ejmech.2009.03.042

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  8 in total

1.  A facile, regioselective synthesis of novel 3-(N-phenylcarboxamide)pyrazolo[1,5-a]pyrimidine analogs in the presence of KHSO4 in aqueous media assisted by ultrasound and their antibacterial activities.

Authors:  Shunan Kaping; Ivee Boiss; Laishram Indira Singha; Philippe Helissey; Jai N Vishwakarma
Journal:  Mol Divers       Date:  2015-10-28       Impact factor: 2.943

2.  Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity.

Authors:  Wei-Bin Mo; Chun-Hua Su; Jia-Yan Huang; Jun Liu; Zhen-Feng Chen; Ke-Guang Cheng
Journal:  Chem Cent J       Date:  2016-11-21       Impact factor: 4.215

3.  Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives.

Authors:  Mohamed A M Abdel Reheim; Safaa M Baker
Journal:  Chem Cent J       Date:  2017-11-02       Impact factor: 4.215

4.  18F-labeled pyrazolo[1,5-a]pyrimidine derivatives: synthesis from 2,4-dinitrobenzamide and tosylate precursors and comparative biological evaluation for tumor imaging with positron emission tomography.

Authors:  Jingli Xu; Hang Liu; Guixia Li; Yong He; Rui Ding; Xiao Wang; Man Feng; Shuting Zhang; Yurong Chen; Shilei Li; Mingxia Zhao; Yingruo Li; Chuanmin Qi; Yonghong Dang
Journal:  Molecules       Date:  2012-03-27       Impact factor: 4.411

5.  Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines.

Authors:  Mohamed El-Naggar; Ashraf S Hassan; Hanem M Awad; Mohamed F Mady
Journal:  Molecules       Date:  2018-05-23       Impact factor: 4.411

6.  Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a] pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs.

Authors:  Amira E M Abdallah; Galal H Elgemeie
Journal:  Drug Des Devel Ther       Date:  2018-06-20       Impact factor: 4.162

7.  Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction.

Authors:  Maryna V Murlykina; Oleksandr V Kolomiets; Maryna M Kornet; Yana I Sakhno; Sergey M Desenko; Victoriya V Dyakonenko; Svetlana V Shishkina; Oleksandr A Brazhko; Vladimir I Musatov; Alexander V Tsygankov; Erik V Van der Eycken; Valentyn A Chebanov
Journal:  Beilstein J Org Chem       Date:  2019-06-12       Impact factor: 2.883

8.  Quantum chemical studies and spectroscopic investigations on 22-amino-3-methyl-5-nitropyridine by density functional theory.

Authors:  S Sivaprakash; S Prakash; S Mohan; Sujin P Jose
Journal:  Heliyon       Date:  2019-07-29
  8 in total

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