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Literature DB >> 19398140

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research.

Tiago G Fernandes¹, Maria Margarida Diogo, Douglas S Clark, Jonathan S Dordick, Joaquim M S Cabral.

Abstract

Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19398140 PMCID： PMC5333994 DOI： 10.1016/j.tibtech.2009.02.009

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

72 in total

1. Polyplexes and lipoplexes for mammalian gene delivery: from traditional to microarray screening.

Authors: S E How; B Yingyongnarongkul; M A Fara; J J Díaz-Mochón; S Mittoo; M Bradley
Journal: Comb Chem High Throughput Screen Date: 2004-08 Impact factor: 1.339

2. Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction.

Authors: Daniel G Anderson; David Putnam; Erin B Lavik; Tahir A Mahmood; Robert Langer
Journal: Biomaterials Date: 2005-01-21 Impact factor: 12.479

Review 3. Small-molecule screening: advances in microarraying and cell-imaging technologies.

Authors: Rebecca L Nicholson; Martin Welch; Mark Ladlow; David R Spring
Journal: ACS Chem Biol Date: 2007-01-23 Impact factor: 5.100

4. High-throughput screening of gene function in stem cells using clonal microarrays.

Authors: Randolph S Ashton; Joseph Peltier; Christopher A Fasano; Analeah O'Neill; Joshua Leonard; Sally Temple; David V Schaffer; Ravi S Kane
Journal: Stem Cells Date: 2007-08-02 Impact factor: 6.277

5. Enhancing the reliability and throughput of neurosphere culture on hydrogel microwell arrays.

Authors: Myriam Cordey; Monika Limacher; Stefan Kobel; Verdon Taylor; Matthias P Lutolf
Journal: Stem Cells Date: 2008-07-31 Impact factor: 6.277

Review 6. Derive and conquer: sourcing and differentiating stem cells for therapeutic applications.

Authors: Irina Klimanskaya; Nadia Rosenthal; Robert Lanza
Journal: Nat Rev Drug Discov Date: 2008-02 Impact factor: 84.694

7. Complex gel permeation assays for screening combinatorial libraries.

Authors: M E Schurdak; M J Voorbach; L Gao; X Cheng; K M Comess; S M Rottinghaus; U Warrior; H N Truong; D J Burns; B A Beutel
Journal: J Biomol Screen Date: 2001-10

Review 8. Use and application of stem cells in toxicology.

Authors: Julio C Davila; Gabriela G Cezar; Mark Thiede; Stephen Strom; Toshio Miki; James Trosko
Journal: Toxicol Sci Date: 2004-03-10 Impact factor: 4.849

9. Microarraying the cellular microenvironment.

Authors: Jae-Hyung Jang; David V Schaffer
Journal: Mol Syst Biol Date: 2006-07-04 Impact factor: 11.429

10. Detection and characterization of cellular immune responses using peptide-MHC microarrays.

Authors: Yoav Soen; Daniel S Chen; Daniel L Kraft; Mark M Davis; Patrick O Brown
Journal: PLoS Biol Date: 2003-12-22 Impact factor: 8.029

66 in total

1. Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules.

Authors: George A Truskey
Journal: Int J High Throughput Screen Date: 2010-10-01

Review 2. Engineering stem cell niches in bioreactors.

Authors: Meimei Liu; Ning Liu; Ru Zang; Yan Li; Shang-Tian Yang
Journal: World J Stem Cells Date: 2013-10-26 Impact factor: 5.326

3. Suspended microfluidics.

Authors: Benjamin P Casavant; Erwin Berthier; Ashleigh B Theberge; Jean Berthier; Sara I Montanez-Sauri; Lauren L Bischel; Kenneth Brakke; Curtis J Hedman; Wade Bushman; Nancy P Keller; David J Beebe
Journal: Proc Natl Acad Sci U S A Date: 2013-05-31 Impact factor: 11.205

4. Laser printing of three-dimensional multicellular arrays for studies of cell-cell and cell-environment interactions.

Authors: Martin Gruene; Michael Pflaum; Christian Hess; Stefanos Diamantouros; Sabrina Schlie; Andrea Deiwick; Lothar Koch; Mathias Wilhelmi; Stefan Jockenhoevel; Axel Haverich; Boris Chichkov
Journal: Tissue Eng Part C Methods Date: 2011-06-29 Impact factor: 3.056

5. Microengineering methods for cell-based microarrays and high-throughput drug-screening applications.

Authors: Feng Xu; JinHui Wu; ShuQi Wang; Naside Gozde Durmus; Umut Atakan Gurkan; Utkan Demirci
Journal: Biofabrication Date: 2011-07-01 Impact factor: 9.954

6. 3D material cytometry (3DMaC): a very high-replicate, high-throughput analytical method using microfabricated, shape-specific, cell-material niches.

Authors: Kirsten Parratt; Jenny Jeong; Peng Qiu; Krishnendu Roy
Journal: Lab Chip Date: 2017-08-08 Impact factor: 6.799