Literature DB >> 17243780

Small-molecule screening: advances in microarraying and cell-imaging technologies.

Rebecca L Nicholson1, Martin Welch, Mark Ladlow, David R Spring.   

Abstract

Cell-permeable small molecules can be used to modulate protein function selectively, rapidly, reversibly, and conditionally with temporal and quantitative control in biological systems. The identification of these chemical probes can require the screening of large numbers of small molecules. With the advent of new technologies, small-molecule high-throughput screening is widely available. This Review focuses on the emerging technologies of microarray screening platforms and high-content screening formats.

Mesh：

Year:  2007        PMID： 17243780     DOI： 10.1021/cb600321j

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  12 in total

Review 1.  Small-molecule microarrays as tools in ligand discovery.

Authors:  Arturo J Vegas; Jason H Fuller; Angela N Koehler
Journal:  Chem Soc Rev       Date:  2008-05-20       Impact factor: 54.564

2.  High-throughput in vivo screening of targeted molecular imaging agents.

Authors:  M Karen J Gagnon; Sven H Hausner; Jan Marik; Craig K Abbey; John F Marshall; Julie L Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-07       Impact factor: 11.205

3.  Quantification of lipid droplets and associated proteins in cellular models of obesity via high-content/high-throughput microscopy and automated image analysis.

Authors:  Patrick M McDonough; Ramses M Agustin; Randall S Ingermanson; Patricia A Loy; Benjamin M Buehrer; James B Nicoll; Natalie L Prigozhina; Ivana Mikic; Jeffrey H Price
Journal:  Assay Drug Dev Technol       Date:  2009-10       Impact factor: 1.738

Review 4.  Techniques for molecular imaging probe design.

Authors:  Fred Reynolds; Kimberly A Kelly
Journal:  Mol Imaging       Date:  2011-12       Impact factor: 4.488

5.  Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.

Authors:  Jermont Chen; Anne H Armstrong; Angela N Koehler; Michael H Hecht
Journal:  J Am Chem Soc       Date:  2010-11-09       Impact factor: 15.419

6.  Accelerating the development of novel molecular imaging probes: a role for high-throughput screening.

Authors:  H Charles Manning; Adam Lander; Eliot McKinley; Nathan J Mutic
Journal:  J Nucl Med       Date:  2008-08-14       Impact factor: 10.057

Review 7.  High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research.

Authors:  Tiago G Fernandes; Maria Margarida Diogo; Douglas S Clark; Jonathan S Dordick; Joaquim M S Cabral
Journal:  Trends Biotechnol       Date:  2009-05-03       Impact factor: 19.536

Review 8.  Droplet interface bilayers.

Authors:  Hagan Bayley; Brid Cronin; Andrew Heron; Matthew A Holden; William L Hwang; Ruhma Syeda; James Thompson; Mark Wallace
Journal:  Mol Biosyst       Date:  2008-09-05

9.  Expanding discriminative dimensions for analysis and imaging.

Authors:  Jérôme Querard; Arnaud Gautier; Thomas Le Saux; Ludovic Jullien
Journal:  Chem Sci       Date:  2015-03-18       Impact factor: 9.825

10.  Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.

Authors:  Cuiping Pan; Jesper V Olsen; Henrik Daub; Matthias Mann
Journal:  Mol Cell Proteomics       Date:  2009-08-03       Impact factor: 5.911
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