Literature DB >> 19396894

Rational design of an organometallic glutathione transferase inhibitor.

Wee Han Ang1, Lorien J Parker, Anastasia De Luca, Lucienne Juillerat-Jeanneret, Craig J Morton, Mario Lo Bello, Michael W Parker, Paul J Dyson.   

Abstract

Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.

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Year:  2009        PMID： 19396894     DOI： 10.1002/anie.200900185

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  12 in total

1.  Metabolization of [Ru(eta(6)-C (6)H (5)CF (3))(pta)Cl (2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand.

Authors:  Alexander E Egger; Christian G Hartinger; Anna K Renfrew; Paul J Dyson
Journal:  J Biol Inorg Chem       Date:  2010-04-06       Impact factor: 3.358

2.  Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos.

Authors:  Golara Golbaghi; Irène Pitard; Matthieu Lucas; Mohammad Mehdi Haghdoost; Yossef López de Los Santos; Nicolas Doucet; Shunmoogum A Patten; J Thomas Sanderson; Annie Castonguay
Journal:  Eur J Med Chem       Date:  2020-01-03       Impact factor: 6.514

3.  Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS.

Authors:  Michael Groessl; Mattia Terenghi; Angela Casini; Lisa Elviri; Ryszard Lobinski; Paul J Dyson
Journal:  J Anal At Spectrom       Date:  2010-03       Impact factor: 4.023

4.  Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme.

Authors:  Lorien J Parker; Alessio Bocedi; David B Ascher; Jade B Aitken; Hugh H Harris; Mario Lo Bello; Giorgio Ricci; Craig J Morton; Michael W Parker
Journal:  Protein Sci       Date:  2016-12-14       Impact factor: 6.725

5.  "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

Authors:  David E Mortenson; Gabriel J Brighty; Lars Plate; Grant Bare; Wentao Chen; Suhua Li; Hua Wang; Benjamin F Cravatt; Stefano Forli; Evan T Powers; K Barry Sharpless; Ian A Wilson; Jeffery W Kelly
Journal:  J Am Chem Soc       Date:  2017-12-21       Impact factor: 15.419

6.  A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis.

Authors:  Soumya Chatterjee; Ilaria Biondi; Paul J Dyson; Arindam Bhattacharyya
Journal:  J Biol Inorg Chem       Date:  2011-03-25       Impact factor: 3.358

7.  Classification of Metal-based Drugs According to Their Mechanisms of Action.

Authors:  Eszter Boros; Paul J Dyson; Gilles Gasser
Journal:  Chem       Date:  2019-11-07       Impact factor: 22.804

8.  Chlorambucil conjugates of dinuclear p-cymene ruthenium trithiolato complexes: synthesis, characterization and cytotoxicity study in vitro and in vivo.

Authors:  David Stíbal; Bruno Therrien; Georg Süss-Fink; Patrycja Nowak-Sliwinska; Paul J Dyson; Eva Čermáková; Martina Řezáčová; Pavel Tomšík
Journal:  J Biol Inorg Chem       Date:  2016-04-04       Impact factor: 3.358

Review 9.  Organometallic anticancer compounds.

Authors:  Gilles Gasser; Ingo Ott; Nils Metzler-Nolte
Journal:  J Med Chem       Date:  2010-11-15       Impact factor: 7.446

10.  Altered DNA binding and amplification of human breast cancer suppressor gene BRCA1 induced by a novel antitumor compound, [Ru(η(6)-p-phenylethacrynate)Cl(2)(pta)].

Authors:  Korawan Chakree; Chitchamai Ovatlarnporn; Paul J Dyson; Adisorn Ratanaphan
Journal:  Int J Mol Sci       Date:  2012-10-15       Impact factor: 5.923
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