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Literature DB >> 19396893

The natural products beauveriolide I and III: a new class of beta-amyloid-lowering compounds.

Daniel P Witter¹, Yanping Chen, Joseph K Rogel, Grant E Boldt, Paul Wentworth.

Abstract

Attacking Alzheimer's by ACAT: The aggregation of beta-amyloid peptides, especially Abeta(42), into senile plaques is a hallmark of Alzheimer's disease (AD). We show that the fungal natural products beauveriolides I and III can potently decrease Abeta secretion from cells expressing human amyloid precursor protein; this offers a potential new scaffold for the development of compounds with proven bioavailability for the treatment of AD.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19396893 PMCID： PMC2812801 DOI： 10.1002/cbic.200900139

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

21 in total

Review 1. The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.

Authors: Benjamin Wolozin; James Brown; Catherine Theisler; Simone Silberman
Journal: CNS Drug Rev Date: 2004

2. Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979.

Authors: I Namatame; H Tomoda; S Si; Y Yamaguchi; R Masuma; S Omura
Journal: J Antibiot (Tokyo) Date: 1999-01 Impact factor: 2.649

3. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.

Authors: Daryl A Bosco; Douglas M Fowler; Qinghai Zhang; Jorge Nieva; Evan T Powers; Paul Wentworth; Richard A Lerner; Jeffery W Kelly
Journal: Nat Chem Biol Date: 2006-03-26 Impact factor: 15.040

4. Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers.

Authors: Taichi Ohshiro; Ichiji Namatame; Kenichiro Nagai; Takafumi Sekiguchi; Takayuki Doi; Takashi Takahashi; Kazuaki Akasaka; Lawrence L Rudel; Hiroshi Tomoda; Satoshi Omura
Journal: J Org Chem Date: 2006-09-29 Impact factor: 4.354

5. Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C.

Authors: I Namatame; H Tomoda; H Arai; K Inoue; S Omura
Journal: J Biochem Date: 1999-02 Impact factor: 3.387

6. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

Authors: Birgit Hutter-Paier; Henri J Huttunen; Luigi Puglielli; Christopher B Eckman; Doo Yeon Kim; Alexander Hofmeister; Robert D Moir; Sarah B Domnitz; Matthew P Frosch; Manfred Windisch; Dora M Kovacs
Journal: Neuron Date: 2004-10-14 Impact factor: 17.173

7. Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages.

Authors: Ichiji Namatame; Hiroshi Tomoda; Shun Ishibashi; Satoshi Omura
Journal: Proc Natl Acad Sci U S A Date: 2004-01-12 Impact factor: 11.205

8. Evidence for ozone formation in human atherosclerotic arteries.

Authors: Paul Wentworth; Jorge Nieva; Cindy Takeuchi; Roger Galve; Anita D Wentworth; Ralph B Dilley; Giacomo A DeLaria; Alan Saven; Bernard M Babior; Kim D Janda; Albert Eschenmoser; Richard A Lerner
Journal: Science Date: 2003-11-07 Impact factor: 47.728

Review 9. Human RAS superfamily proteins and related GTPases.

Authors: John Colicelli
Journal: Sci STKE Date: 2004-09-07

10. Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

Authors: Qinghai Zhang; Evan T Powers; Jorge Nieva; Mary E Huff; Maria A Dendle; Jan Bieschke; Charles G Glabe; Albert Eschenmoser; Paul Wentworth; Richard A Lerner; Jeffery W Kelly
Journal: Proc Natl Acad Sci U S A Date: 2004-03-19 Impact factor: 11.205

4 in total