Fatigue in Parkinson disease, stroke, and traumatic brain injury.

Fatigue is a serious, QoL-limiting symptom of many neurologic conditions. Physicians should be thorough and consistent in their assessment for this problem and not let motor symptoms monopolize an office visit. Although the use of pharmacology to treat this problem has predominantly only anecdotal evidence of efficacy, several nonpharmacologic interventions may prove helpful. The directions of future research should aim to create clear treatment guidelines using the pharmacologic agents available.