Literature DB >> 19389341

Outbreak of Clostridium difficile 027 in North Zealand, Denmark, 2008-2009.

S Bacci1, G St-Martin, B Olesen, B Bruun, K E P Olsen, E Møller Nielsen, K Mølbak.   

Abstract

We report an outbreak of Clostridium difficile PCR ribotype 027 in Denmark. The outbreak includes to date 73 cases from the area north of Copenhagen, but there may be related cases elsewhere in Zealand. Most infections are healthcare-associated and in patients who previously received antibiotic treatment. The strain is resistant to moxifloxacin, erythromycin, and clindamycin, and carries genes for toxin A, toxin B, and for the binary toxin. The antimicrobial pattern differs from that of the strain involved in a small cluster in Denmark in 2006-2007. Because of this outbreak, hygienic measures in the involved hospitals have been reinforced. Nationwide, microbiological laboratories were alerted to the outbreak and encouraged to send isolates for toxin profiling and PCR ribotyping.

Entities:  

Mesh：

Year:  2009        PMID： 19389341

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


  11 in total

1.  A multiplex, internally controlled real-time PCR assay for detection of toxigenic Clostridium difficile and identification of hypervirulent strain 027/ST-1.

Authors:  A M Hoegh; J B Nielsen; A Lester; A Friis-Møller; K Schønning
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-09-22       Impact factor: 3.267

Review 2.  The changing epidemiology of Clostridium difficile infections.

Authors:  J Freeman; M P Bauer; S D Baines; J Corver; W N Fawley; B Goorhuis; E J Kuijper; M H Wilcox
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

3.  Multiplex PCR method for detection of Clostridium difficile tcdA, tcdB, cdtA, and cdtB and internal in-frame deletion of tcdC.

Authors:  Søren Persson; Joan N Jensen; Katharina E P Olsen
Journal:  J Clin Microbiol       Date:  2011-10-05       Impact factor: 5.948

4.  Clostridium difficile testing in the clinical laboratory by use of multiple testing algorithms.

Authors:  Susan M Novak-Weekley; Elizabeth M Marlowe; John M Miller; Joven Cumpio; Jim H Nomura; Paula H Vance; Alice Weissfeld
Journal:  J Clin Microbiol       Date:  2010-01-13       Impact factor: 5.948

5.  Binary toxin and death after Clostridium difficile infection.

Authors:  Sabrina Bacci; Kåre Mølbak; Marianne K Kjeldsen; Katharina E P Olsen
Journal:  Emerg Infect Dis       Date:  2011-06       Impact factor: 6.883

6.  Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.

Authors:  M D Cairns; M D Preston; C L Hall; D N Gerding; P M Hawkey; H Kato; H Kim; E J Kuijper; T D Lawley; H Pituch; S Reid; B Kullin; T V Riley; K Solomon; P J Tsai; J S Weese; R A Stabler; B W Wren
Journal:  J Clin Microbiol       Date:  2016-12-28       Impact factor: 5.948

Review 7.  Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread.

Authors:  Archie C A Clements; Ricardo J Soares Magalhães; Andrew J Tatem; David L Paterson; Thomas V Riley
Journal:  Lancet Infect Dis       Date:  2010-06       Impact factor: 25.071

Review 8.  Community-acquired Clostridium difficile infection: an increasing public health threat.

Authors:  Arjun Gupta; Sahil Khanna
Journal:  Infect Drug Resist       Date:  2014-03-17       Impact factor: 4.003

Review 9.  Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C. difficile Infection.

Authors:  Simon D Baines; Mark H Wilcox
Journal:  Antibiotics (Basel)       Date:  2015-07-10

10.  Emergence and spread of moxifloxacin-resistant Clostridium difficile ribotype 231 in Sweden between 2006 and 2015.

Authors:  H Harvala; E Alm; T Åkerlund; K Rizzardi
Journal:  New Microbes New Infect       Date:  2016-09-16
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