| Literature DB >> 19385671 |
Tyler A Johnson1, Taro Amagata, Koneni V Sashidhara, Allen G Oliver, Karen Tenney, Teatulohi Matainaho, Kenny Kean-Hooi Ang, James H McKerrow, Phillip Crews.
Abstract
A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensis has yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1-3 were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19385671 PMCID： PMC3762577 DOI： 10.1021/ol900446d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005