Literature DB >> 18715038

The unexpected isolation of CTP-431, a novel thiopyrone from the sponge Cacospongia mycofijiensis.

Tyler A Johnson1, Taro Amagata, Allen G Oliver, Karen Tenney, Frederick A Valeriote, Phillip Crews.   

Abstract

A reinvestigation of a Fijian collection of Cacospongia mycofijiensis has yielded the known mycothiazole and a novel heterocyclic, CTP-431 (1). Its structure including absolute configuration as 8R,9R,10S,13S was established using NMR data, calculated DFT (13)C chemical shifts and results from X-ray crystallography. It is possible that the tricyclic skeleton of CTP-431 (1) is biosynthetically related to the macrolide latrunculin A, however the thiopyrone moiety of 1 has no previous precedent in natural products chemistry.

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Year:  2008        PMID： 18715038     DOI： 10.1021/jo801096m

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  6 in total

1.  Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.

Authors:  Tyler A Johnson; Johann Sohn; Wayne D Inman; Samarkand A Estee; Steven T Loveridge; Helene C Vervoort; Karen Tenney; Junke Liu; Kenny Kean-Hooi Ang; Joseline Ratnam; Walter M Bray; Nadine C Gassner; Young Y Shen; R Scott Lokey; James H McKerrow; Kyria Boundy-Mills; Arif Nukanto; Atit Kanti; Heddy Julistiono; Leonardus B S Kardono; Leonard F Bjeldanes; Phillip Crews
Journal:  J Nat Prod       Date:  2011-11-30       Impact factor: 4.050

2.  The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis.

Authors:  Tyler A Johnson; Taro Amagata; Koneni V Sashidhara; Allen G Oliver; Karen Tenney; Teatulohi Matainaho; Kenny Kean-Hooi Ang; James H McKerrow; Phillip Crews
Journal:  Org Lett       Date:  2009-05-07       Impact factor: 6.005

Review 3.  A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.

Authors:  Koneni V Sashidhara; Kimberly N White; Phillip Crews
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

4.  Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.

Authors:  Taro Amagata; Tyler A Johnson; Robert H Cichewicz; Karen Tenney; Susan L Mooberry; Joseph Media; Matthew Edelstein; Frederick A Valeriote; Phillip Crews
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

5.  Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products.

Authors:  Tyler A Johnson; Micaela V C Morgan; Natalie A Aratow; Samarkand A Estee; Koneni V Sashidhara; Steven T Loveridge; Nathaniel L Segraves; Phillip Crews
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

Review 6.  Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.

Authors:  Mohammad Ferdous Mehbub; Jie Lei; Christopher Franco; Wei Zhang
Journal:  Mar Drugs       Date:  2014-08-19       Impact factor: 5.118
  6 in total

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