AIMS: To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF. METHODS AND RESULTS: The International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) included 18,900 patients without and 1705 patients with a history of AF suffering from hypertension and other risk factors for cardiovascular disease in 26 countries worldwide from September 2005 to March 2006. Heart rate, blood pressure, urinary albumin excretion, and an estimated glomerular filtration rate were determined among other parameters. The prevalence of MAU was higher at higher heart rate in both patients with and without a history of AF. Prevalence of MAU was about 10% higher in patients with a history of AF (P < 0.001). Male gender, the presence of diabetes mellitus, a higher heart rate, and a higher diastolic blood pressure were independently associated with increased odds for MAU in patients without and with a history of AF. CONCLUSION: The prevalence of MAU in hypertensive patients with cardiovascular risk factors is related to heart rate and significantly higher in patients with a history of AF.
AIMS: To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF. METHODS AND RESULTS: The International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) included 18,900 patients without and 1705 patients with a history of AF suffering from hypertension and other risk factors for cardiovascular disease in 26 countries worldwide from September 2005 to March 2006. Heart rate, blood pressure, urinary albumin excretion, and an estimated glomerular filtration rate were determined among other parameters. The prevalence of MAU was higher at higher heart rate in both patients with and without a history of AF. Prevalence of MAU was about 10% higher in patients with a history of AF (P < 0.001). Male gender, the presence of diabetes mellitus, a higher heart rate, and a higher diastolic blood pressure were independently associated with increased odds for MAU in patients without and with a history of AF. CONCLUSION: The prevalence of MAU in hypertensivepatients with cardiovascular risk factors is related to heart rate and significantly higher in patients with a history of AF.
Authors: Björn Zethelius; Soffia Gudbjörnsdottir; Björn Eliasson; Katarina Eeg-Olofsson; Ann-Marie Svensson; Jan Cederholm Journal: Diabetologia Date: 2016-02-03 Impact factor: 10.122
Authors: Christian Ukena; F Mahfoud; M Kindermann; S Gräber; I Kindermann; M Schneider; R Schmieder; P Bramlage; M Volpe; M Thoenes; M Böhm Journal: Clin Res Cardiol Date: 2010-07-11 Impact factor: 5.460
Authors: Jan-Christian Reil; Florian Custodis; Karl Swedberg; Michel Komajda; Jeffrey S Borer; Ian Ford; Luigi Tavazzi; Ulrich Laufs; Michael Böhm Journal: Clin Res Cardiol Date: 2010-09-01 Impact factor: 5.460
Authors: Graham S Hillis; Jun Hata; Mark Woodward; Vlado Perkovic; Hisatomi Arima; Clara K Chow; Sophia Zoungas; Anushka Patel; Neil R Poulter; Giuseppe Mancia; Bryan Williams; John Chalmers Journal: J Am Heart Assoc Date: 2012-10-25 Impact factor: 5.501