Literature DB >> 19383357

The CALM and CALM/AF10 interactor CATS is a marker for proliferation.

Leticia Fröhlich Archangelo1, Philipp A Greif, Michael Hölzel, Thomas Harasim, Elisabeth Kremmer, Gerhard K H Przemeck, Dirk Eick, Aniruddha Jayant Deshpande, Christian Buske, Martin Hrabé de Angelis, Sara Teresinha Olalla Saad, Stefan K Bohlander.   

Abstract

The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.

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Year:  2008        PMID: 19383357      PMCID: PMC5527775          DOI: 10.1016/j.molonc.2008.08.001

Source DB:  PubMed          Journal:  Mol Oncol        ISSN: 1574-7891            Impact factor:   6.603


  51 in total

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5.  The CALM and CALM/AF10 interactor CATS is a marker for proliferation.

Authors:  Leticia Fröhlich Archangelo; Philipp A Greif; Michael Hölzel; Thomas Harasim; Elisabeth Kremmer; Gerhard K H Przemeck; Dirk Eick; Aniruddha Jayant Deshpande; Christian Buske; Martin Hrabé de Angelis; Sara Teresinha Olalla Saad; Stefan K Bohlander
Journal:  Mol Oncol       Date:  2008-09-04       Impact factor: 6.603

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