Literature DB >> 19383317

The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.

Jonas M la Cour1, Berit R Høj, Jens Mollerup, Ronald Simon, Guido Sauter, Martin W Berchtold.   

Abstract

The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

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Year:  2007        PMID： 19383317      PMCID： PMC5543837          DOI： 10.1016/j.molonc.2007.08.002

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  32 in total

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4.  Towards a proteome-scale map of the human protein-protein interaction network.

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Authors:  M Missotten; A Nichols; K Rieger; R Sadoul
Journal:  Cell Death Differ       Date:  1999-02       Impact factor: 15.828

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9.  Tissue microarrays for high-throughput molecular profiling of tumor specimens.

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Authors:  Ingrid Draeby; Yvonne L Woods; Jonas M la Cour; Jens Mollerup; Jean-Christophe Bourdon; Martin W Berchtold
Journal:  Arch Biochem Biophys       Date:  2007-08-21       Impact factor: 4.013
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  26 in total

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Journal:  Tumour Biol       Date:  2011-12-13

3.  Structural and Functional Study of Apoptosis-linked Gene-2·Heme-binding Protein 2 Interactions in HIV-1 Production.

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8.  The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.

Authors:  Jonas M la Cour; Berit R Høj; Jens Mollerup; Ronald Simon; Guido Sauter; Martin W Berchtold
Journal:  Mol Oncol       Date:  2007-08-19       Impact factor: 6.603

9.  Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.

Authors:  Kui Zhang; Bin Zhou; Shaoqing Shi; Yaping Song; Lin Zhang
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Authors:  Srikant Ambatipudi; Moritz Gerstung; Ravindra Gowda; Prathamesh Pai; Anita M Borges; Alejandro A Schäffer; Niko Beerenwinkel; Manoj B Mahimkar
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