BACKGROUND: Due to the rarity of esophageal gastrointestinal stromal tumors (GISTs), their clinical course and treatment are poorly understood. We have assessed our experience in the diagnosis and management of esophageal GISTs. METHODS: We performed a retrospective chart review of patients diagnosed with esophageal GISTs who underwent surgical resection. RESULTS: We identified 7 patients (6 males and 1 female) who underwent surgical procedures due to esophageal GISTs between 2001 and 2003; their median age was 46 years (range, 39 to 68 years). Four patients presented with dysphagia. Two patients were diagnosed with GIST by endoscopic biopsy before surgery. Five patients underwent enucleation, and two underwent esophagectomy. All tumors were resected completely and no patient received perioperative imatinib therapy. Median postoperative follow-up was 4.4 years (range, 2.2 to 7.0 years), during which two patients were diagnosed with recurrences. CONCLUSIONS: Esophageal GIST is a rare disease, and complete surgical resection is the standard treatment. Regular follow-up is needed even if resection is complete and negative margins are achieved.
BACKGROUND: Due to the rarity of esophageal gastrointestinal stromal tumors (GISTs), their clinical course and treatment are poorly understood. We have assessed our experience in the diagnosis and management of esophageal GISTs. METHODS: We performed a retrospective chart review of patients diagnosed with esophageal GISTs who underwent surgical resection. RESULTS: We identified 7 patients (6 males and 1 female) who underwent surgical procedures due to esophageal GISTs between 2001 and 2003; their median age was 46 years (range, 39 to 68 years). Four patients presented with dysphagia. Two patients were diagnosed with GIST by endoscopic biopsy before surgery. Five patients underwent enucleation, and two underwent esophagectomy. All tumors were resected completely and no patient received perioperative imatinib therapy. Median postoperative follow-up was 4.4 years (range, 2.2 to 7.0 years), during which two patients were diagnosed with recurrences. CONCLUSIONS: Esophageal GIST is a rare disease, and complete surgical resection is the standard treatment. Regular follow-up is needed even if resection is complete and negative margins are achieved.
Authors: Simon Lott; Michael Schmieder; Benjamin Mayer; Doris Henne-Bruns; Uwe Knippschild; Abbas Agaimy; Matthias Schwab; Klaus Kramer Journal: Am J Cancer Res Date: 2014-12-15 Impact factor: 6.166
Authors: Carlo Vallicelli; Federico Coccolini; Fausto Catena; Luca Ansaloni; Giulia Montori; Salomone Di Saverio; Antonio D Pinna Journal: World J Emerg Surg Date: 2011-01-07 Impact factor: 5.469
Authors: Kyriakos Neofytou; Mafalda Costa Neves; Alexandros Giakoustidis; Charlotte Benson; Satvinder Mudan Journal: Case Rep Oncol Med Date: 2015-05-05
Authors: Charalampos G Markakis; Eleftherios D Spartalis; Emmanouil Liarmakopoulos; Evangelia G Kavoura; Periklis Tomos Journal: Case Rep Surg Date: 2013-04-30