Paul M Wehn1, J Du Bois. 1. Amgen, Inc. 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
Abstract
Weaving an intricate web: A stereoselective synthesis of (-)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.
Weaving an intricate web: A stereoselective synthesis of (-)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a n class="Chemical">Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.
Authors: Daniel T Cohen; Chad C Eichman; Eric M Phillips; Emily R Zarefsky; Karl A Scheidt Journal: Angew Chem Int Ed Engl Date: 2012-06-14 Impact factor: 15.336
Authors: Rasika Fernando; Jonathan M Shirley; Emilio Torres; Hollie K Jacobs; Aravamudan S Gopalan Journal: Tetrahedron Lett Date: 2012-11-21 Impact factor: 2.415
Authors: Morgan Jouanneau; Brandon McClary; Jeremy Chris P Reyes; Rong Chen; Yuling Chen; William Plunkett; Xin Cheng; Andrew Z Milinichik; Earl F Albone; Jun O Liu; Daniel Romo Journal: Bioorg Med Chem Lett Date: 2016-02-23 Impact factor: 2.823