Literature DB >> 19377449

Fragment-based drug discovery takes a virtual turn.

Maurizio Pellecchia.   

Abstract

Mesh：

Year:  2009        PMID： 19377449     DOI： 10.1038/nchembio0509-274

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  5 in total

Review 1.  Fragment-based lead discovery.

Authors:  David C Rees; Miles Congreve; Christopher W Murray; Robin Carr
Journal:  Nat Rev Drug Discov       Date:  2004-08       Impact factor: 84.694

Review 2.  Virtual screening of chemical libraries.

Authors:  Brian K Shoichet
Journal:  Nature       Date:  2004-12-16       Impact factor: 49.962

Review 3.  A decade of fragment-based drug design: strategic advances and lessons learned.

Authors:  Philip J Hajduk; Jonathan Greer
Journal:  Nat Rev Drug Discov       Date:  2007-02-09       Impact factor: 84.694

Review 4.  Perspectives on NMR in drug discovery: a technique comes of age.

Authors:  Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L James; Steve W Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

5.  Molecular docking and ligand specificity in fragment-based inhibitor discovery.

Authors:  Yu Chen; Brian K Shoichet
Journal:  Nat Chem Biol       Date:  2009-03-22       Impact factor: 15.040
  5 in total
  6 in total

1.  Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.

Authors:  Moreno Wichert; Nikolaus Krall; Willy Decurtins; Raphael M Franzini; Francesca Pretto; Petra Schneider; Dario Neri; Jörg Scheuermann
Journal:  Nat Chem       Date:  2015-01-26       Impact factor: 24.427

2.  An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.

Authors:  Marcela Vettorazzi; Emilio Angelina; Santiago Lima; Tomas Gonec; Jan Otevrel; Pavlina Marvanova; Tereza Padrtova; Petr Mokry; Pavel Bobal; Lina M Acosta; Alirio Palma; Justo Cobo; Janette Bobalova; Jozef Csollei; Ivan Malik; Sergio Alvarez; Sarah Spiegel; Josef Jampilek; Ricardo D Enriz
Journal:  Eur J Med Chem       Date:  2017-08-10       Impact factor: 6.514

3.  Retrospective molecular docking study of WY-25105 ligand to β-secretase and bias of the three-dimensional structure flexibility.

Authors:  Leo Ghemtio; Nicolas Muzet
Journal:  J Mol Model       Date:  2013-04-07       Impact factor: 1.810

4.  In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine.

Authors:  Natalia Mast; Marlin Linger; Matthew Clark; Jeffrey Wiseman; C David Stout; Irina A Pikuleva
Journal:  Mol Pharmacol       Date:  2012-08-02       Impact factor: 4.436

5.  Investigation of the novel lead of melanocortin 1 receptor for pigmentary disorders.

Authors:  Hsin-Chieh Tang; Calvin Yu-Chian Chen
Journal:  Evid Based Complement Alternat Med       Date:  2014-02-17       Impact factor: 2.629

6.  In silico design for adenosine monophosphate-activated protein kinase agonist from traditional chinese medicine for treatment of metabolic syndromes.

Authors:  Hsin-Chieh Tang; Calvin Yu-Chian Chen
Journal:  Evid Based Complement Alternat Med       Date:  2014-05-11       Impact factor: 2.629
  6 in total

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