Literature DB >> 15286733

Fragment-based lead discovery.

David C Rees1, Miles Congreve, Christopher W Murray, Robin Carr.   

Abstract

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Year:  2004        PMID： 15286733     DOI： 10.1038/nrd1467

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  143 in total

1.  Hot spot analysis for driving the development of hits into leads in fragment-based drug discovery.

Authors:  David R Hall; Chi Ho Ngan; Brandon S Zerbe; Dima Kozakov; Sandor Vajda
Journal:  J Chem Inf Model       Date:  2011-12-15       Impact factor: 4.956

Review 2.  Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach.

Authors:  I M Kapetanovic
Journal:  Chem Biol Interact       Date:  2006-12-16       Impact factor: 5.192

Review 3.  Ligand discovery and virtual screening using the program LIDAEUS.

Authors:  P Taylor; E Blackburn; Y G Sheng; S Harding; K-Y Hsin; D Kan; S Shave; M D Walkinshaw
Journal:  Br J Pharmacol       Date:  2007-11-26       Impact factor: 8.739

Review 4.  Automated robotic harvesting of protein crystals-addressing a critical bottleneck or instrumentation overkill?

Authors:  Robert Viola; Peter Carman; Jace Walsh; Daniel Frankel; Bernhard Rupp
Journal:  J Struct Funct Genomics       Date:  2007-10-27

Review 5.  Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Authors:  Tom L Blundell; Bancinyane L Sibanda; Rinaldo Wander Montalvão; Suzanne Brewerton; Vijayalakshmi Chelliah; Catherine L Worth; Nicholas J Harmer; Owen Davies; David Burke
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-03-29       Impact factor: 6.237

6.  Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.

Authors:  Kerim Babaoglu; Anton Simeonov; John J Irwin; Michael E Nelson; Brian Feng; Craig J Thomas; Laura Cancian; M Paola Costi; David A Maltby; Ajit Jadhav; James Inglese; Christopher P Austin; Brian K Shoichet
Journal:  J Med Chem       Date:  2008-03-12       Impact factor: 7.446

7.  A noncompetitive inhibitor for Mycobacterium tuberculosis's class IIa fructose 1,6-bisphosphate aldolase.

Authors:  Glenn C Capodagli; Wafik G Sedhom; Mary Jackson; Kateri A Ahrendt; Scott D Pegan
Journal:  Biochemistry       Date:  2013-12-24       Impact factor: 3.162

Review 8.  Perspectives on NMR in drug discovery: a technique comes of age.

Authors:  Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L James; Steve W Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

9.  Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.

Authors:  Yuemin Bian; Zhiwei Feng; Peng Yang; Xiang-Qun Xie
Journal:  AAPS J       Date:  2017-05-30       Impact factor: 4.009

10.  Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy.

Authors:  Melissa M Lee; Jessica L Childs-Disney; Alexei Pushechnikov; Jonathan M French; Krzysztof Sobczak; Charles A Thornton; Matthew D Disney
Journal:  J Am Chem Soc       Date:  2009-12-02       Impact factor: 15.419
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