| Literature DB >> 19376703 |
Marlys Hammond1, Jaclyn R Patterson, Sharada Manns, Tram H Hoang, David G Washburn, Walter Trizna, Lindsay Glace, Eugene T Grygielko, Rakesh Nagilla, Melanie Nord, Harvey E Fries, Douglas J Minick, Nicholas J Laping, Jeffrey D Bray, Scott K Thompson.
Abstract
Two classes of amino acid-derived heterocyclic progesterone receptor ligands were developed to address the metabolic issues posed by the dimethyl amide functionality of the lead compound (1). The tetrazole-derived ligands behaved as potent partial agonists, while the 1,2,4-triazole ligands behaved as potent full agonists.Entities:
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Year: 2009 PMID： 19376703 DOI： 10.1016/j.bmcl.2009.03.146
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823