| Literature DB >> 19376178 |
Konstantinos Douroudis1, Antti-Pekka Laine, Mirkka Heinonen, Robert Hermann, Kati Lipponen, Riitta Veijola, Olli Simell, Mikael Knip, Raivo Uibo, Jorma Ilonen, Kalle Kisand.
Abstract
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type 1 diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CTBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1 C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type 1 diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland.Entities:
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Year: 2009 PMID： 19376178 DOI： 10.1016/j.humimm.2009.04.023
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850