OBJECTIVE: The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS: Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. RESULTS: We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease. CONCLUSION: Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.
OBJECTIVE: The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS: Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. RESULTS: We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease. CONCLUSION: Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.
Authors: Alka Malhotra; Andy P Peiffer; Darin T Ryujin; Tami Elsner; Richard E Kanner; Mark F Leppert; Sandra J Hasstedt Journal: Am J Respir Crit Care Med Date: 2003-06-05 Impact factor: 21.405
Authors: K M Lee; E Chuang; M Griffin; R Khattri; D K Hong; W Zhang; D Straus; L E Samelson; C B Thompson; J A Bluestone Journal: Science Date: 1998-12-18 Impact factor: 47.728
Authors: Suzy M Teutsch; David R Booth; Bruce H Bennetts; Robert N S Heard; Graeme J Stewart Journal: J Neuroimmunol Date: 2004-03 Impact factor: 3.478
Authors: Edwin K Silverman; Lyle J Palmer; Jonathan D Mosley; Matthew Barth; Jody M Senter; Alison Brown; Jeffrey M Drazen; David J Kwiatkowski; Harold A Chapman; Edward J Campbell; Michael A Province; D C Rao; John J Reilly; Leo C Ginns; Frank E Speizer; Scott T Weiss Journal: Am J Hum Genet Date: 2002-03-25 Impact factor: 11.025