| Literature DB >> 19376076 |
Romy Razakandrainibe1, Vincent Thonier, Arsène Ratsimbasoa, Emma Rakotomalala, Elisabeth Ravaoarisoa, Rogelin Raherinjafy, Herilalaina Andrianantenaina, Odette Voahanginirina, Tiana Eugénie Rahasana, Jean François Carod, Olivier Domarle, Didier Menard.
Abstract
The aim of this study was to provide baseline information of the epidemiological situation of malaria in Madagascar using serological markers. We carried out cross-sectional studies in schoolchildren from eight sites in the four different malarious epidemiological strata of Madagascar. We studied the prevalence of anti-MSP1 antibodies to assess the burden, and anti-CSP antibodies to estimate the transmission intensity, of malaria. The overall prevalence of each antibody tested was 46.1% for anti-PfMSP-1, 15.2% for anti-PvMSP-1, 14.9% for anti-PfCSP, 4.9% for anti-PvCSP and 2.4% for anti-PmCSP. The prevalence of the five antibodies varied significantly between the sites (P<10(-6)). We also found significant effects of ethnic origin on the prevalence of anti-PfMSP1 antibodies. With regular testing in the same target populations, this data will be particularly useful for managing the elimination strategy supported by the Malagasy Government.Entities:
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Year: 2009 PMID： 19376076 DOI： 10.1016/j.actatropica.2009.04.007
Source DB: PubMed Journal: Acta Trop ISSN： 0001-706X Impact factor: 3.112