BACKGROUND/ OBJECTIVE: Abnormal cerebral haemodynamics in very preterm infants undergoing neonatal intensive care have been associated with adverse outcome, but cerebral blood flow (CBF) is difficult to assess at the cotside. Spatially resolved spectroscopy (SRS) continuously measures cerebral tissue oxygen saturation expressed as tissue oxygenation index (TOI, %), and TOI would reflect changes in CBF with constant cerebral metabolic demand. We aimed to evaluate the relationship between simultaneous measurements of CBF (Transonic System) and TOI (Hamamatsu NIRO-200) in newborn lambs (n = 8). We hypothesised that alterations in CBF of different magnitudes and frequencies would be reflected as changes of TOI in both time domain and frequency domain analyses. METHODS: A silicon cuff positioned around the common brachiocephalic artery was inflated to induce 10-30% reductions in cerebral perfusion pressure so as to produce mild-to-moderate variations of CBF. Relationships between changes in CBF and TOI were evaluated in the time domain (Pearson correlation) and frequency domain (Coherence). RESULTS: In time domain analysis, there was significant correlation between DeltaTOI (%) and DeltaCBF (%) (R2 = 0.69, P < 0.001). In frequency domain analysis, CBF-TOI coherence was > or = 0.5 at frequencies below 0.1 Hz, but <0.5 at higher frequencies. CONCLUSIONS: We conclude that overall TOI changes are concordant with CBF variations, when arterial oxygen saturation and cerebral oxygen consumption are constant. While TOI reflects CBF, it is more sensitive to variations of CBF of low frequency (<0.1 Hz) than to more rapid, higher frequency changes.
BACKGROUND/ OBJECTIVE: Abnormal cerebral haemodynamics in very preterm infants undergoing neonatal intensive care have been associated with adverse outcome, but cerebral blood flow (CBF) is difficult to assess at the cotside. Spatially resolved spectroscopy (SRS) continuously measures cerebral tissue oxygen saturation expressed as tissue oxygenation index (TOI, %), and TOI would reflect changes in CBF with constant cerebral metabolic demand. We aimed to evaluate the relationship between simultaneous measurements of CBF (Transonic System) and TOI (Hamamatsu NIRO-200) in newborn lambs (n = 8). We hypothesised that alterations in CBF of different magnitudes and frequencies would be reflected as changes of TOI in both time domain and frequency domain analyses. METHODS: A silicon cuff positioned around the common brachiocephalic artery was inflated to induce 10-30% reductions in cerebral perfusion pressure so as to produce mild-to-moderate variations of CBF. Relationships between changes in CBF and TOI were evaluated in the time domain (Pearson correlation) and frequency domain (Coherence). RESULTS: In time domain analysis, there was significant correlation between DeltaTOI (%) and DeltaCBF (%) (R2 = 0.69, P < 0.001). In frequency domain analysis, CBF-TOI coherence was > or = 0.5 at frequencies below 0.1 Hz, but <0.5 at higher frequencies. CONCLUSIONS: We conclude that overall TOI changes are concordant with CBF variations, when arterial oxygen saturation and cerebral oxygen consumption are constant. While TOI reflects CBF, it is more sensitive to variations of CBF of low frequency (<0.1 Hz) than to more rapid, higher frequency changes.
Authors: Rong Zhang; Julie H Zuckerman; Kenichi Iwasaki; Thad E Wilson; Craig G Crandall; Benjamin D Levine Journal: Circulation Date: 2002-10-01 Impact factor: 29.690
Authors: Janet S Soul; Peter E Hammer; Miles Tsuji; J Philip Saul; Haim Bassan; Catherine Limperopoulos; Donald N Disalvo; Marianne Moore; Patricia Akins; Steven Ringer; Joseph J Volpe; Felicia Trachtenberg; Adré J du Plessis Journal: Pediatr Res Date: 2007-04 Impact factor: 3.756
Authors: L Meng; M Cannesson; B S Alexander; Z Yu; Z N Kain; A E Cerussi; B J Tromberg; W W Mantulin Journal: Br J Anaesth Date: 2011-06-03 Impact factor: 9.166
Authors: Massimo Antonelli; Elie Azoulay; Marc Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel De Backer; François Lemaire; Herwig Gerlach; Goran Hedenstierna; Michael Joannidis; Duncan Macrae; Jordi Mancebo; Salvatore M Maggiore; Alexandre Mebazaa; Jean-Charles Preiser; Jerôme Pugin; Jan Wernerman; Haibo Zhang Journal: Intensive Care Med Date: 2010-02-23 Impact factor: 17.440
Authors: Liesbeth Thewissen; Gunnar Naulaers; Dries Hendrikx; Alexander Caicedo; Keith Barrington; Geraldine Boylan; Po-Yin Cheung; David Corcoran; Afif El-Khuffash; Aisling Garvey; Jozef Macko; Neil Marlow; Jan Miletin; Colm P F O'Donnell; John M O'Toole; Zbyněk Straňák; David Van Laere; Hana Wiedermannova; Eugene Dempsey Journal: Pediatr Res Date: 2021-04-20 Impact factor: 3.756
Authors: Samantha K Barton; Timothy J M Moss; Stuart B Hooper; Kelly J Crossley; Andrew W Gill; Martin Kluckow; Valerie Zahra; Flora Y Wong; Gerhard Pichler; Robert Galinsky; Suzanne L Miller; Mary Tolcos; Graeme R Polglase Journal: PLoS One Date: 2014-11-07 Impact factor: 3.240
Authors: Atul Malhotra; Margie Castillo-Melendez; Beth J Allison; Amy E Sutherland; Ilias Nitsos; Yen Pham; Courtney A McDonald; Michael C Fahey; Graeme R Polglase; Graham Jenkin; Suzanne L Miller Journal: Stem Cell Res Ther Date: 2020-01-08 Impact factor: 6.832