PURPOSE: To assess the reliability of microaneurysm turnover, computed from color fundus photographs, in evaluating diabetic retinopathy in patients with type 2 diabetes and nonproliferative retinopathy. METHODS: A new method (MA-Tracker) was developed to count microaneurysms by mapping their locations through image co-registration. To compute the reliability of microaneurysm turnover, 3 different graders were asked to earmark microaneurysms on the same set of color fundus photographs. RESULTS: The total numbers of microaneurysms earmarked in each of 5 visits suggest that microaneurysms remain stable over time (p >or= 0.138). However, an analysis of each microaneurysm showed that only 29.4% remained at the same location. By computing the formation and disappearance rates of microaneurysms (2.3 and 1.7 microaneurysms/year, respectively), a significant turnover of microaneurysms was found. CONCLUSIONS: The formation and disappearance rates of microaneurysms obtained from color fundus photographs using MA-Tracker show very good agreement between different graders, and can be used as indicators of microaneurysm turnover in the initial stages of diabetic retinopathy. (c) 2009 S. Karger AG, Basel.
PURPOSE: To assess the reliability of microaneurysm turnover, computed from color fundus photographs, in evaluating diabetic retinopathy in patients with type 2 diabetes and nonproliferative retinopathy. METHODS: A new method (MA-Tracker) was developed to count microaneurysms by mapping their locations through image co-registration. To compute the reliability of microaneurysm turnover, 3 different graders were asked to earmark microaneurysms on the same set of color fundus photographs. RESULTS: The total numbers of microaneurysms earmarked in each of 5 visits suggest that microaneurysms remain stable over time (p >or= 0.138). However, an analysis of each microaneurysm showed that only 29.4% remained at the same location. By computing the formation and disappearance rates of microaneurysms (2.3 and 1.7 microaneurysms/year, respectively), a significant turnover of microaneurysms was found. CONCLUSIONS: The formation and disappearance rates of microaneurysms obtained from color fundus photographs using MA-Tracker show very good agreement between different graders, and can be used as indicators of microaneurysm turnover in the initial stages of diabetic retinopathy. (c) 2009 S. Karger AG, Basel.
Authors: Maziyar M Khansari; William O'Neill; Richard Penn; Felix Chau; Norman P Blair; Mahnaz Shahidi Journal: Biomed Opt Express Date: 2016-06-16 Impact factor: 3.732
Authors: Michael Dubow; Alexander Pinhas; Nishit Shah; Robert F Cooper; Alexander Gan; Ronald C Gentile; Vernon Hendrix; Yusufu N Sulai; Joseph Carroll; Toco Y P Chui; Joseph B Walsh; Rishard Weitz; Alfredo Dubra; Richard B Rosen Journal: Invest Ophthalmol Vis Sci Date: 2014-03-04 Impact factor: 4.799
Authors: Toco Yuen Ping Chui; Alexander Pinhas; Alexander Gan; Moataz Razeen; Nishit Shah; Eric Cheang; Chun L Liu; Alfredo Dubra; Richard B Rosen Journal: Ophthalmic Physiol Opt Date: 2016-01-24 Impact factor: 3.117
Authors: M L Rasmussen; R Broe; U Frydkjaer-Olsen; B S Olsen; H B Mortensen; T Peto; J Grauslund Journal: Graefes Arch Clin Exp Ophthalmol Date: 2014-06-05 Impact factor: 3.117
Authors: Dawn A Sim; Pearse A Keane; Adnan Tufail; Catherine A Egan; Lloyd Paul Aiello; Paolo S Silva Journal: Curr Diab Rep Date: 2015-03 Impact factor: 5.430
Authors: B A Mysona; S Matragoon; M Stephens; I N Mohamed; A Farooq; M L Bartasis; A Y Fouda; A Y Shanab; D G Espinosa-Heidmann; A B El-Remessy Journal: Biomed Res Int Date: 2015-03-17 Impact factor: 3.411