Literature DB >> 19371076

Kinetics of self-immolation: faster signal relay over a longer linear distance?

Ho Yong Lee1, Xuan Jiang, Dongwhan Lee.   

Abstract

A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

Entities:  

Year:  2009        PMID： 19371076     DOI： 10.1021/ol900433g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Readily accessible fluorescent probes for sensitive biological imaging of hydrogen peroxide.

Authors:  Kevin B Daniel; Arpita Agrawal; Marianne Manchester; Seth M Cohen
Journal:  Chembiochem       Date:  2013-02-21       Impact factor: 3.164

2.  Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.

Authors:  Jody L Major Jourden; Kevin B Daniel; Seth M Cohen
Journal:  Chem Commun (Camb)       Date:  2011-06-16       Impact factor: 6.222

3.  Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach.

Authors:  Jody L Major Jourden; Seth M Cohen
Journal:  Angew Chem Int Ed Engl       Date:  2010-09-10       Impact factor: 15.336

4.  Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide.

Authors:  Caroline de Gracia Lux; Shivanjali Joshi-Barr; Trung Nguyen; Enas Mahmoud; Eric Schopf; Nadezda Fomina; Adah Almutairi
Journal:  J Am Chem Soc       Date:  2012-09-17       Impact factor: 15.419

5.  Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition.

Authors:  Siddharth S Matikonda; Douglas L Orsi; Verena Staudacher; Imogen A Jenkins; Franziska Fiedler; Jiayi Chen; Allan B Gamble
Journal:  Chem Sci       Date:  2014-11-14       Impact factor: 9.825

6.  A mitochondrial-targetable dual functional near-infrared fluorescent probe to monitor pH and H2O2 in living cells and mice.

Authors:  Xueyuan Bi; Yingying Wang; Dandan Wang; Liming Liu; Wen Zhu; Junjie Zhang; Xiaoming Zha
Journal:  RSC Adv       Date:  2020-07-17       Impact factor: 3.361
  6 in total

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