Literature DB >> 1937053

Murine retroviral vectors expressing the tax1 gene of human T-cell leukemia virus type 1.

T Akagi1, H Nyunoya, K Shimotohno.   

Abstract

Murine retroviral vectors which express the tax1 gene of human T-cell leukemia virus type 1 (HTLV-1) have been constructed. A significant increase in virus titer was achieved by inserting a portion of the gag region of Moloney murine leukemia virus. Using these vectors, tax1 was stably introduced into primary human T-cells derived from peripheral blood lymphocytes. Expression of the functional tax1 in infected cells was confirmed by trans-activation of HTLV-1 long terminal repeat-directed transcription. These vectors provide a useful means of investigating the function of tax1 in natural target cells for HTLV-1.

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Year:  1991        PMID： 1937053     DOI： 10.1016/0378-1119(91)90207-r

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  3 in total

1.  GD2 ganglioside on human T-lymphotropic virus type I-infected T cells: possible activation of beta-1,4-N-acetylgalactosaminyltransferase gene by p40tax.

Authors:  K Furukawa; T Akagi; Y Nagata; Y Yamada; K Shimotohno; N K Cheung; H Shiku; K Furukawa
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

2.  Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway.

Authors:  T Akagi; K Shimotohno
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

3.  Enhancement of T cell receptor signaling of tumor-infiltrating lymphocytes by retrovirally mediated fyn gene transduction.

Authors:  K Fujita; H Ikarashi; K Takakuwa; S Kodama; T Akagi; T Yamamoto; K Tanaka
Journal:  Jpn J Cancer Res       Date:  1994-11
  3 in total

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