Literature DB >> 19368783

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.

Janet E McElhaney1, Catherine Ewen, Xin Zhou, Kevin P Kane, Dongxu Xie, W David Hager, Mary Beth Barry, Alison Kleppinger, Yazhen Wang, R Chris Bleackley.   

Abstract

This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p=0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults.

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Year:  2009        PMID： 19368783      PMCID： PMC2800816          DOI： 10.1016/j.vaccine.2009.01.136

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  30 in total

1.  Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly.

Authors:  Donna M Murasko; Erica D Bernstein; Elizabeth M Gardner; Peter Gross; Gary Munk; Sandra Dran; Elias Abrutyn
Journal:  Exp Gerontol       Date:  2002 Jan-Mar       Impact factor: 4.032

2.  Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines.

Authors:  Maria Saurwein-Teissl; Thomas L Lung; Florentine Marx; Claudio Gschösser; Esther Asch; Imrich Blasko; Walther Parson; Günther Böck; Diether Schönitzer; Emanuelle Trannoy; Beatrix Grubeck-Loebenstein
Journal:  J Immunol       Date:  2002-06-01       Impact factor: 5.422

3.  Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals.

Authors:  J J Goronzy; J W Fulbright; C S Crowson; G A Poland; W M O'Fallon; C M Weyand
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

4.  The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccines.

Authors:  Kristin L Nichol
Journal:  Vaccine       Date:  2003-05-01       Impact factor: 3.641

5.  Granzyme B: a marker of risk for influenza in institutionalized older adults.

Authors:  J E McElhaney; S Gravenstein; C M Upshaw; J W Hooton; P Krause; P Drinka; R C Bleackley
Journal:  Vaccine       Date:  2001-06-14       Impact factor: 3.641

6.  Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

Authors:  Barbara J Johnson; Elaine O Costelloe; David R Fitzpatrick; John B A G Haanen; Ton N M Schumacher; Lorena E Brown; Anne Kelso
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-24       Impact factor: 11.205

7.  A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B.

Authors:  Catherine Ewen; Kevin P Kane; Irene Shostak; Philip J Griebel; Edward M Bertram; Tania H Watts; R C Bleackley; Janet E McElhaney
Journal:  J Immunol Methods       Date:  2003-05-01       Impact factor: 2.303

Review 8.  Cytotoxic T lymphocytes: all roads lead to death.

Authors:  Michele Barry; R Chris Bleackley
Journal:  Nat Rev Immunol       Date:  2002-06       Impact factor: 53.106

Review 9.  Granzyme B: a natural born killer.

Authors:  Sarah J Lord; Ray V Rajotte; Gregory S Korbutt; R Chris Bleackley
Journal:  Immunol Rev       Date:  2003-06       Impact factor: 12.988

10.  Mortality associated with influenza and respiratory syncytial virus in the United States.

Authors:  William W Thompson; David K Shay; Eric Weintraub; Lynnette Brammer; Nancy Cox; Larry J Anderson; Keiji Fukuda
Journal:  JAMA       Date:  2003-01-08       Impact factor: 56.272
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  87 in total

1.  GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults.

Authors:  Hayedeh Behzad; Anke L W Huckriede; Laura Haynes; Beth Gentleman; Krysta Coyle; Jan C Wilschut; Tobias R Kollmann; Steven G Reed; Janet E McElhaney
Journal:  J Infect Dis       Date:  2011-12-05       Impact factor: 5.226

2.  Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans.

Authors:  Daniela Frasca; Alain Diaz; Maria Romero; Ana Marie Landin; Mitch Phillips; Suzanne C Lechner; John G Ryan; Bonnie B Blomberg
Journal:  Vaccine       Date:  2010-10-23       Impact factor: 3.641

3.  Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.

Authors:  Adrian J Reber; Tatiana Chirkova; Jin Hyang Kim; Weiping Cao; Renata Biber; David K Shay; Suryaprakash Sambhara
Journal:  Aging Dis       Date:  2011-09-30       Impact factor: 6.745

Review 4.  Correlates of protection induced by vaccination.

Authors:  Stanley A Plotkin
Journal:  Clin Vaccine Immunol       Date:  2010-05-12

5.  Clinical and immunologic predictors of influenza illness among vaccinated older adults.

Authors:  Zainab Shahid; Alison Kleppinger; Beth Gentleman; Ann R Falsey; Janet E McElhaney
Journal:  Vaccine       Date:  2010-07-31       Impact factor: 3.641

6.  Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses.

Authors:  Adrian J Reber; Jin Hyang Kim; Renata Biber; H Keipp Talbot; Laura A Coleman; Tatiana Chirkova; F Liaini Gross; Evelene Steward-Clark; Weiping Cao; Stacie Jefferson; Vic Veguilla; Eric Gillis; Jennifer Meece; Yaohui Bai; Heather Tatum; Kathy Hancock; James Stevens; Sarah Spencer; Jufu Chen; Paul Gargiullo; Elise Braun; Marie R Griffin; Maria Sundaram; Edward A Belongia; David K Shay; Jacqueline M Katz; Suryaprakash Sambhara
Journal:  Open Forum Infect Dis       Date:  2015-04-15       Impact factor: 3.835

Review 7.  Aging, cytomegalovirus (CMV) and influenza vaccine responses.

Authors:  Daniela Frasca; Bonnie B Blomberg
Journal:  Hum Vaccin Immunother       Date:  2016-03-03       Impact factor: 3.452

Review 8.  The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

Authors:  Janet E McElhaney; Xin Zhou; H Keipp Talbot; Ernst Soethout; R Chris Bleackley; David J Granville; Graham Pawelec
Journal:  Vaccine       Date:  2012-01-27       Impact factor: 3.641

9.  New influenza vaccines: promises, perils, and pitfalls.

Authors:  Gregory A Poland; Pritish K Tosh
Journal:  Vaccine       Date:  2012-02-01       Impact factor: 3.641

10.  Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons.

Authors:  Sapna P Sadarangani; Inna G Ovsyannikova; Krista Goergen; Diane E Grill; Gregory A Poland
Journal:  Hum Vaccin Immunother       Date:  2016-03-03       Impact factor: 3.452
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