| Literature DB >> 19367310 |
Hirotaka Komaba1, Masafumi Fukagawa.
Abstract
Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulating fetuin-A forms fetuin-mineral complex in the serum of uremic rats and thereby inhibits vascular calcification. This suggests that fetuin-mineral complex may reflect extraosseous calcification stress, opening new perspectives on vascular calcification in uremia.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19367310 DOI： 10.1038/ki.2009.52
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612