| Literature DB >> 26399239 |
Catherine Quinlan1, Stephen D Marks2, Kjell Tullus2.
Abstract
Juvenile-onset systemic lupus erythematosus (SLE) is an aggressive multisystem autoimmune disease. Despite improvements in outcomes for adult patients, children with SLE continue to have a lower life expectancy than adults with SLE, with more aggressive disease, a higher incidence of lupus nephritis and there is an emerging awareness of their increased risk of cardiovascular disease (CVD). In this review, we discuss the evidence for an increased risk of CVD in SLE, its pathogenesis, and the clinical approach to its management.Entities:
Keywords: Adipokines; Cardiovascular; Lipids; Physical activity; Systemic lupus erythematosus
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Year: 2015 PMID: 26399239 DOI: 10.1007/s00467-015-3202-7
Source DB: PubMed Journal: Pediatr Nephrol ISSN: 0931-041X Impact factor: 3.714