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Literature DB >> 19365706

A case report suggesting the occurrence of epithelial-mesenchymal transition in obstructive nephropathy.

Tsutomu Inoue¹, Hirokazu Okada¹, Tsuneo Takenaka¹, Yusuke Watanabe¹, Hiromichi Suzuki².

Abstract

Epithelial-mesenchymal transition (EMT) has been well investigated using cultured kidney epithelial cell lines and the mouse obstructive nephropathy model. The role of EMT in the genesis or progression of human renal fibrosis remains controversial. We report a case of obstructive nephropathy that occurred in a pregnant woman. Renal tissue obtained by percutaneous renal biopsy after the delivery showed marked interstitial fibrosis and obstructive tubuli. Immunofluorescence images clearly demonstrated S100A4-positive tubular epithelial cells in these specimens. With regard to human obstructive nephropathy, this is the first report which proves that tubular epithelial cells become positive for the fibroblast-specific marker. EMT is probably a common event not only in mouse but also in human.

Entities: Disease Species

Mesh：

Substances：

Year: 2009 PMID： 19365706 DOI： 10.1007/s10157-009-0168-4

Source DB: PubMed Journal: Clin Exp Nephrol ISSN： 1342-1751 Impact factor: 2.801

16 in total

1. Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction.

Authors: M Grigorian; S Andresen; E Tulchinsky; M Kriajevska; C Carlberg; C Kruse; M Cohn; N Ambartsumian; A Christensen; G Selivanova; E Lukanidin
Journal: J Biol Chem Date: 2001-03-05 Impact factor: 5.157

2. Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy.

Authors: H Kaneto; H Ohtani; A Fukuzaki; S Ishidoya; A Takeda; Y Ogata; H Nagura; S Orikasa
Journal: Kidney Int Date: 1999-12 Impact factor: 10.612

3. Setting a trap for tissue fibrosis.

Authors: Eric G Neilson
Journal: Nat Med Date: 2005-04 Impact factor: 53.440

4. Immunocytochemical distribution of the calcium-binding protein p9Ka in normal rat tissues: variation in the cellular location in different tissues.

Authors: F E Gibbs; R Barraclough; A Platt-Higgins; P S Rudland; M C Wilkinson; E W Parry
Journal: J Histochem Cytochem Date: 1995-02 Impact factor: 2.479

5. Antibodies against macrophages that overlap in specificity with fibroblasts.

Authors: Tsutomu Inoue; David Plieth; Christo D Venkov; Carol Xu; Eric G Neilson
Journal: Kidney Int Date: 2005-06 Impact factor: 10.612

6. Effect of Mts1 on the structure and activity of nonmuscle myosin II.

Authors: H L Ford; D L Silver; B Kachar; J R Sellers; S B Zain
Journal: Biochemistry Date: 1997-12-23 Impact factor: 3.162

7. Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease.

Authors: Michele Rossini; Boonyarit Cheunsuchon; Ellen Donnert; Li-Jun Ma; James W Thomas; Eric G Neilson; Agnes B Fogo
Journal: Kidney Int Date: 2005-12 Impact factor: 10.612

A case report suggesting the occurrence of epithelial-mesenchymal transition in obstructive nephropathy.

1. Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction.

2. Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy.

3. Setting a trap for tissue fibrosis.

4. Immunocytochemical distribution of the calcium-binding protein p9Ka in normal rat tissues: variation in the cellular location in different tissues.

5. Antibodies against macrophages that overlap in specificity with fibroblasts.

6. Effect of Mts1 on the structure and activity of nonmuscle myosin II.

7. Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease.

Review 8. Obstructive acute renal failure by a gravid uterus: a case report and review.

9. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.

10. Identification and characterization of a fibroblast marker: FSP1.

Review 1. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.

Review 2. The role of the epithelial-to-mesenchymal transition (EMT) in diseases of the salivary glands.

Review 3. Epithelial-mesenchymal transition in tissue repair and fibrosis.

4. Phenotypic transition of the collecting duct epithelium in congenital urinary tract obstruction.

Review 5. Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?