Literature DB >> 14764882

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.

Neil A Bhowmick1, Anna Chytil, David Plieth, Agnieszka E Gorska, Nancy Dumont, Scott Shappell, M Kay Washington, Eric G Neilson, Harold L Moses.   

Abstract

Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-beta type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-beta responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an increased abundance of stromal cells. Activation of paracrine hepatocyte growth factor (HGF) signaling was identified as one possible mechanism for stimulation of epithelial proliferation. Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues.

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Year:  2004        PMID： 14764882     DOI： 10.1126/science.1090922

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  581 in total

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