Literature DB >> 19364865

Gene Context and DNA rearrangements in the carbapenemase locus of division II strains of Bacteroides fragilis.

Nuria García1, Gloria Gutiérrez, María Lorenzo, Santiago Vadillo, Segundo Píriz, Alberto Quesada.   

Abstract

The cfiA gene is clustered in a bicistronic operon encoding an N-acetyltransferase and an O-acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and ISBf9. Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS942 at its promoter was a determinant for expression of carbapenemase activity.

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Year:  2009        PMID： 19364865      PMCID： PMC2687242          DOI： 10.1128/AAC.01514-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

Review 1.  SMR-type multidrug resistance pumps.

Authors:  Y J Chung; M H Saier
Journal:  Curr Opin Drug Discov Devel       Date:  2001-03

Review 2.  Structure and functions of the GNAT superfamily of acetyltransferases.

Authors:  Matthew W Vetting; Luiz Pedro S de Carvalho; Michael Yu; Subray S Hegde; Sophie Magnet; Steven L Roderick; John S Blanchard
Journal:  Arch Biochem Biophys       Date:  2005-01-01       Impact factor: 4.013

3.  Genetic determinants for cfxA expression in Bacteroides strains isolated from human infections.

Authors:  Nuria García; Gloria Gutiérrez; María Lorenzo; José E García; Segundo Píriz; Alberto Quesada
Journal:  J Antimicrob Chemother       Date:  2008-09-04       Impact factor: 5.790

4.  Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics.

Authors:  Michele Sugantino; Steven L Roderick
Journal:  Biochemistry       Date:  2002-02-19       Impact factor: 3.162

5.  New insertion sequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains.

Authors:  Naoki Kato; Kikuo Yamazoe; Chang-Gyun Han; Eiichi Ohtsubo
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

6.  A recent fixation of cfiA genes in a monophyletic cluster of Bacteroides fragilis is correlated with the presence of multiple insertion elements.

Authors:  R Ruimy; I Podglajen; J Breuil; R Christen; E Collatz
Journal:  J Bacteriol       Date:  1996-04       Impact factor: 3.490

7.  ISfinder: the reference centre for bacterial insertion sequences.

Authors:  P Siguier; J Perochon; L Lestrade; J Mahillon; M Chandler
Journal:  Nucleic Acids Res       Date:  2006-01-01       Impact factor: 16.971
  7 in total
  3 in total

Review 1.  Anaerobic infections: update on treatment considerations.

Authors:  Elisabeth Nagy
Journal:  Drugs       Date:  2010-05-07       Impact factor: 9.546

Review 2.  Horizontal gene transfers with or without cell fusions in all categories of the living matter.

Authors:  Joseph G Sinkovics
Journal:  Adv Exp Med Biol       Date:  2011       Impact factor: 2.622

3.  A novel Bacteroides metallo-β-lactamase (MBL) and its gene (crxA) in Bacteroides xylanisolvens revealed by genomic sequencing and functional analysis.

Authors:  József Sóki; Uwe Lang; Ulrike Schumacher; István Nagy; Ágnes Berényi; Tamás Fehér; Katalin Burián; Elisabeth Nagy
Journal:  J Antimicrob Chemother       Date:  2022-05-29       Impact factor: 5.758
  3 in total

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