Literature DB >> 19361554

Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment.

Mark Levine1, Michael Graham Espey, Qi Chen.   

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Year:  2009        PMID： 19361554      PMCID： PMC2981594          DOI： 10.1016/j.freeradbiomed.2009.04.001

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


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  31 in total

1.  Genetic Control of Biochemical Reactions in Neurospora.

Authors:  G W Beadle; E L Tatum
Journal:  Proc Natl Acad Sci U S A       Date:  1941-11-15       Impact factor: 11.205

Review 2.  New concepts in the biology and biochemistry of ascorbic acid.

Authors:  M Levine
Journal:  N Engl J Med       Date:  1986-04-03       Impact factor: 91.245

3.  Vitamin C and cancer.

Authors:  R E Wittes
Journal:  N Engl J Med       Date:  1985-01-17       Impact factor: 91.245

4.  Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.

Authors:  M Levine; C Conry-Cantilena; Y Wang; R W Welch; P W Washko; K R Dhariwal; J B Park; A Lazarev; J F Graumlich; J King; L R Cantilena
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

5.  Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

Authors:  Julien Verrax; Julie Stockis; Aurélie Tison; Henryk S Taper; Pedro Buc Calderon
Journal:  Biochem Pharmacol       Date:  2006-07-07       Impact factor: 5.858

6.  Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival.

Authors:  Sotiria Sotiriou; Suzana Gispert; Jun Cheng; Yaohui Wang; Amy Chen; Shelley Hoogstraten-Miller; Georgina F Miller; Oran Kwon; Mark Levine; Susan H Guttentag; Robert L Nussbaum
Journal:  Nat Med       Date:  2002-05       Impact factor: 53.440

7.  Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.

Authors:  Qi Chen; Michael Graham Espey; Andrew Y Sun; Chaya Pooput; Kenneth L Kirk; Murali C Krishna; Deena Beneda Khosh; Jeanne Drisko; Mark Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-04       Impact factor: 11.205

8.  Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial.

Authors:  E T Creagan; C G Moertel; J R O'Fallon; A J Schutt; M J O'Connell; J Rubin; S Frytak
Journal:  N Engl J Med       Date:  1979-09-27       Impact factor: 91.245

9.  Phase I clinical trial of i.v. ascorbic acid in advanced malignancy.

Authors:  L J Hoffer; M Levine; S Assouline; D Melnychuk; S J Padayatty; K Rosadiuk; C Rousseau; L Robitaille; W H Miller
Journal:  Ann Oncol       Date:  2008-06-09       Impact factor: 32.976

10.  Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

Authors:  Qi Chen; Michael Graham Espey; Andrew Y Sun; Je-Hyuk Lee; Murali C Krishna; Emily Shacter; Peter L Choyke; Chaya Pooput; Kenneth L Kirk; Garry R Buettner; Mark Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-14       Impact factor: 11.205
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  25 in total

Review 1.  The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Authors:  Anthony R Cyr; Frederick E Domann
Journal:  Antioxid Redox Signal       Date:  2011-02-05       Impact factor: 8.401

2.  Combined deficiencies of vitamins b1 and C in well-nourished patients.

Authors:  Karthika Veerapaneni; Thomas M Brown; David P Dooley
Journal:  Prim Care Companion CNS Disord       Date:  2014-07-03

3.  Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

Authors:  Satya S Pathi; Ping Lei; Sandeep Sreevalsan; Gayathri Chadalapaka; Indira Jutooru; Stephen Safe
Journal:  Nutr Cancer       Date:  2011-09-15       Impact factor: 2.900

4.  High-dose ascorbate with low-dose amphotericin B attenuates severity of disease in a model of the reappearance of candidemia during sepsis in the mouse.

Authors:  Asada Leelahavanichkul; Poorichaya Somparn; Tanabodee Bootprapan; Hongbin Tu; Pattarin Tangtanatakul; Ratchanok Nuengjumnong; Navaporn Worasilchai; Khajohn Tiranathanagul; Somchai Eiam-ong; Mark Levine; Ariya Chinampon; Nattachai Srisawat
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-08-01       Impact factor: 3.619

Review 5.  Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

Authors:  Mark Levine; Sebastian J Padayatty; Michael Graham Espey
Journal:  Adv Nutr       Date:  2011-03-10       Impact factor: 8.701

6.  Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer.

Authors:  Michael Graham Espey; Ping Chen; Brian Chalmers; Jeanne Drisko; Andrew Y Sun; Mark Levine; Qi Chen
Journal:  Free Radic Biol Med       Date:  2011-03-12       Impact factor: 7.376

7.  Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.

Authors:  Sebastian J Padayatty; Andrew Y Sun; Qi Chen; Michael Graham Espey; Jeanne Drisko; Mark Levine
Journal:  PLoS One       Date:  2010-07-07       Impact factor: 3.240

Review 8.  SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

Authors:  Ines Batinic-Haberle; Artak Tovmasyan; Emily R H Roberts; Zeljko Vujaskovic; Kam W Leong; Ivan Spasojevic
Journal:  Antioxid Redox Signal       Date:  2013-10-01       Impact factor: 8.401

9.  Ascorbic acid and a cytostatic inhibitor of glycolysis synergistically induce apoptosis in non-small cell lung cancer cells.

Authors:  Saleha B Vuyyuri; Jacob Rinkinen; Erin Worden; Hyekyung Shim; Sukchan Lee; Keith R Davis
Journal:  PLoS One       Date:  2013-06-11       Impact factor: 3.240

10.  Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer.

Authors:  Christopher M Stephenson; Robert D Levin; Thomas Spector; Christopher G Lis
Journal:  Cancer Chemother Pharmacol       Date:  2013-05-14       Impact factor: 3.333
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