Literature DB >> 19360441

Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates.

Yanhong Sun1, Yunfeng Ren, Hua Zhu, Yuanqing Zhang, Guifeng Liu, Chunchun Zhang, Liliang Huang, Jia Xu, Yujin Qi, Yu-Mei Shen.   

Abstract

Beta-elemene, (5S,7R,10S)-(-)-(1-methyl-1-vinyl-2,4-diisopropenylcyclohexane), is an anticancer agent from traditional Chinese herbal medicine. Three novel (99m)Tc(CO)(3)-beta-elemene conjugates were synthesized successfully, and compared with beta-elemene exhibited improved water solubility. A biodistribution and micro single photon emission computed tomography image study showed there is a visible accumulation in Lewis lung cancer tumors.

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Year:  2009        PMID： 19360441     DOI： 10.1007/s00775-009-0502-z

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  14 in total

1.  Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression.

Authors:  Nagavarakishore Pillarsetty; Shangde Cai; Lyudmila Ageyeva; Ronald D Finn; Ronald G Blasberg
Journal:  J Med Chem       Date:  2006-08-24       Impact factor: 7.446

2.  Initial study on naturally occurring products from traditional Chinese herbs and vegetables for chemoprevention.

Authors:  S Zheng; H Yang; S Zhang; X Wang; L Yu; J Lu; J Li
Journal:  J Cell Biochem Suppl       Date:  1997

3.  The pharmacokinetics of a novel anti-tumor agent, beta-elemene, in Sprague-Dawley rats.

Authors:  Kun Wang; Zi Li; Yuren Chen; Chengye Su
Journal:  Biopharm Drug Dispos       Date:  2005-10       Impact factor: 1.627

4.  Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death.

Authors:  G Wang; X Li; F Huang; J Zhao; H Ding; C Cunningham; J E Coad; D C Flynn; E Reed; Q Q Li
Journal:  Cell Mol Life Sci       Date:  2005-04       Impact factor: 9.261

5.  Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase.

Authors:  X Li; G Wang; J Zhao; H Ding; C Cunningham; F Chen; D C Flynn; E Reed; Q Q Li
Journal:  Cell Mol Life Sci       Date:  2005-04       Impact factor: 9.261

6.  Organometallic 99mTc-aquaion labels peptide to an unprecedented high specific activity.

Authors:  A Egli; R Alberto; L Tannahill; R Schibli; U Abram; A Schaffland; R Waibel; D Tourwé; L Jeannin; K Iterbeke; P A Schubiger
Journal:  J Nucl Med       Date:  1999-11       Impact factor: 10.057

Review 7.  New directions in the coordination chemistry of 99mTc: a reflection on technetium core structures and a strategy for new chelate design.

Authors:  Sangeeta Ray Banerjee; Kevin P Maresca; Lynn Francesconi; John Valliant; John W Babich; Jon Zubieta
Journal:  Nucl Med Biol       Date:  2005-01       Impact factor: 2.408

8.  The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity.

Authors:  Liying Xu; Shujuan Tao; Xianming Wang; Zhiying Yu; Minwei Wang; Duo Chen; Yongkui Jing; Jinhua Dong
Journal:  Bioorg Med Chem       Date:  2006-04-17       Impact factor: 3.641

9.  Versatile synthetic approach to new bifunctional chelating agents tailor made for labeling with the fac-[M(CO)(3)](+) core (M = Tc, (99m)Tc, Re): synthesis, in vitro, and in vivo behavior of the model complex [M(APPA)(CO)(3)] (APPA = [(5-amino-pentyl)-pyridin-2-yl-methyl-amino]-acetic acid).

Authors:  Albert Stichelberger; Robert Waibel; Cécile Dumas; P A Schubiger; Roger Schibli
Journal:  Nucl Med Biol       Date:  2003-07       Impact factor: 2.408

10.  Bridging the gap between in vitro and in vivo imaging: isostructural Re and 99mTc complexes for correlating fluorescence and radioimaging studies.

Authors:  Karin A Stephenson; Sangeeta Ray Banerjee; Travis Besanger; Oyebola O Sogbein; Murali K Levadala; Nicole McFarlane; Jennifer A Lemon; Douglas R Boreham; Kevin P Maresca; John D Brennan; John W Babich; Jon Zubieta; John F Valliant
Journal:  J Am Chem Soc       Date:  2004-07-21       Impact factor: 15.419
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  2 in total

Review 1.  Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy.

Authors:  Bingtao Zhai; Yiying Zeng; Zhaowu Zeng; Nana Zhang; Chenxi Li; Yijun Zeng; Yu You; Shuling Wang; Xiabin Chen; Xinbing Sui; Tian Xie
Journal:  Int J Nanomedicine       Date:  2018-10-10

Review 2.  Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification.

Authors:  Ziqiang Bai; Chuansheng Yao; Junlong Zhu; Yuanyuan Xie; Xiang-Yang Ye; Renren Bai; Tian Xie
Journal:  Molecules       Date:  2021-03-10       Impact factor: 4.411
  2 in total

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