Literature DB >> 16913728

Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression.

Nagavarakishore Pillarsetty1, Shangde Cai, Lyudmila Ageyeva, Ronald D Finn, Ronald G Blasberg.   

Abstract

Synthesis of three novel 2'-deoxy-2'-[18F]fluoro-1-beta-D-arabinofuranosyluracil derivatives [18F]FPAU, [18F]FBrVAU, and [18F]FTMAU is reported. The compounds were synthesized by coupling of 1-bromo-2-deoxy-2-fluoro sugars with corresponding silylated uracil derivatives. In vitro cell uptake indicated that all three compounds are taken up selectively in RG2TK+ cells with negligible uptake in RG2 cells. The results indicate that [18F]FBrVAU and [18F]FTMAU have better uptake profiles in comparison to [18F]FPAU and have potential as PET probes for imaging HSV1-tk gene expression.

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Year:  2006        PMID： 16913728     DOI： 10.1021/jm0512847

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

1.  Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression.

Authors:  Ann-Marie Chacko; Wenchao Qu; Hank F Kung
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

2.  Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents.

Authors:  Hua Zhu; Liliang Huang; Yuanqing Zhang; Xiaoping Xu; Yanhong Sun; Yu-Mei Shen
Journal:  J Biol Inorg Chem       Date:  2010-03-01       Impact factor: 3.358

3.  2-18F-Fluoropropionic acid as a PET imaging agent for prostate cancer.

Authors:  Nagavarakishore Pillarsetty; Blesida Punzalan; Steven M Larson
Journal:  J Nucl Med       Date:  2009-09-16       Impact factor: 10.057

4.  Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates.

Authors:  Yanhong Sun; Yunfeng Ren; Hua Zhu; Yuanqing Zhang; Guifeng Liu; Chunchun Zhang; Liliang Huang; Jia Xu; Yujin Qi; Yu-Mei Shen
Journal:  J Biol Inorg Chem       Date:  2009-04-10       Impact factor: 3.358

5.  PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues.

Authors:  Simone Däpp; Cristina Müller; Elisa García Garayoa; Peter Bläuenstein; Veronique Maes; Luc Brans; Dirk A Tourwé; Roger Schibli
Journal:  EJNMMI Res       Date:  2012-06-09       Impact factor: 3.138

6.  Applications of nuclear-based imaging in gene and cell therapy: probe considerations.

Authors:  Alessia Volpe; Naga Vara Kishore Pillarsetty; Jason S Lewis; Vladimir Ponomarev
Journal:  Mol Ther Oncolytics       Date:  2021-02-04       Impact factor: 7.200

7.  TMSOTf assisted synthesis of 2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine ([18F]FAC).

Authors:  Kishore K Gangangari; John L Humm; Steven M Larson; Naga Vara Kishore Pillarsetty
Journal:  PLoS One       Date:  2018-05-01       Impact factor: 3.240
  7 in total

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