| Literature DB >> 19356928 |
Miranda J Sarachine1, Jelena M Janjic, Peter Wipf, Billy W Day.
Abstract
The C-cyclopropylalkylamide scaffold was previously identified as a new structural framework for antiestrogens. A second generation library provided three compounds that bind estrogen receptor (ER)alpha. Further screening of this library identified an ERbeta hit and inspired another round of SAR. A new focused library was tested for binding to the ERs, and for effects on the growth of breast cancer cell lines and protein levels of common cell cycle regulators.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19356928 PMCID： PMC2676897 DOI： 10.1016/j.bmcl.2009.03.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823