Literature DB >> 19356128

Capsid (CA) protein as a novel drug target: recent progress in the research of HIV-1 CA inhibitors.

Jiyan Zhang1, Xinyong Liu, Erik De Clercq.   

Abstract

The capsid (CA) protein is the major structural component of HIV-1 and plays a key role in the regulation of viral life cycle. Inhibition of CA will affect the viral assembly and budding processes, causing decreased viral infectivity. This review describes the structure and function of the HIV-1 CA and latest progress in the discovery of HIV-1 CA inhibitors.

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Year:  2009        PMID： 19356128     DOI： 10.2174/138955709787847958

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

1.  A new functional role of HIV-1 integrase during uncoating of the viral core.

Authors:  Marisa S Briones; Samson A Chow
Journal:  Immunol Res       Date:  2010-12       Impact factor: 2.829

2.  Simulations of HIV capsid protein dimerization reveal the effect of chemistry and topography on the mechanism of hydrophobic protein association.

Authors:  Naiyin Yu; Michael F Hagan
Journal:  Biophys J       Date:  2012-09-19       Impact factor: 4.033

3.  Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.

Authors:  Marisa S Briones; Charles W Dobard; Samson A Chow
Journal:  J Virol       Date:  2010-03-10       Impact factor: 5.103

4.  Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

Authors:  Shujing Xu; Lin Sun; Alexej Dick; Waleed A Zalloum; Tianguang Huang; Megan E Meuser; Xujie Zhang; Yucen Tao; Srinivasulu Cherukupalli; Dang Ding; Xiao Ding; Shenghua Gao; Xiangyi Jiang; Dongwei Kang; Erik De Clercq; Christophe Pannecouque; Simon Cocklin; Xinyong Liu; Peng Zhan
Journal:  Eur J Med Chem       Date:  2021-10-09       Impact factor: 7.088

5.  Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

Authors:  Jimmy P Xu; Jeffrey D Branson; Rae Lawrence; Simon Cocklin
Journal:  Bioorg Med Chem Lett       Date:  2015-12-25       Impact factor: 2.823

6.  Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.

Authors:  Lei Wang; Mary C Casey; Sanjeev Kumar V Vernekar; Rajkumar Lalji Sahani; Jayakanth Kankanala; Karen A Kirby; Haijuan Du; Atsuko Hachiya; Huanchun Zhang; Philip R Tedbury; Jiashu Xie; Stefan G Sarafianos; Zhengqiang Wang
Journal:  Eur J Med Chem       Date:  2020-07-19       Impact factor: 6.514

7.  Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability.

Authors:  Lei Wang; Mary C Casey; Sanjeev Kumar V Vernekar; Rajkumar Lalji Sahani; Karen A Kirby; Haijuan Du; Huanchun Zhang; Philip R Tedbury; Jiashu Xie; Stefan G Sarafianos; Zhengqiang Wang
Journal:  Acta Pharm Sin B       Date:  2020-07-31       Impact factor: 11.413

8.  Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity.

Authors:  Rebeca Bocanegra; María Nevot; Rosa Doménech; Inmaculada López; Olga Abián; Alicia Rodríguez-Huete; Claudio N Cavasotto; Adrián Velázquez-Campoy; Javier Gómez; Miguel Ángel Martínez; José Luis Neira; Mauricio G Mateu
Journal:  PLoS One       Date:  2011-09-08       Impact factor: 3.240

9.  Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Authors:  Jing Li; Xiangyi Jiang; Alexej Dick; Prem Prakash Sharma; Chin-Ho Chen; Brijesh Rathi; Dongwei Kang; Zhao Wang; Xiangkai Ji; Kuo-Hsiung Lee; Simon Cocklin; Xinyong Liu; Peng Zhan
Journal:  Bioorg Med Chem       Date:  2021-09-17       Impact factor: 3.461

10.  GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors.

Authors:  Anastasia Selyutina; Pan Hu; Sorin Miller; Lacy M Simons; Hyun Jae Yu; Judd F Hultquist; KyeongEun Lee; Vineet N KewalRamani; Felipe Diaz-Griffero
Journal:  iScience       Date:  2021-12-09
  10 in total

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