Literature DB >> 19356018

A role for lysosomal phospholipase A2 in drug induced phospholipidosis.

Akira Abe1, Miki Hiraoka, James A Shayman.   

Abstract

Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.

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Year:  2007        PMID： 19356018     DOI： 10.2174/187231207779814292

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN： 1872-3128


  15 in total

Review 1.  Group XV phospholipase A₂, a lysosomal phospholipase A₂.

Authors:  James A Shayman; Robert Kelly; Jessica Kollmeyer; Yongqun He; Akira Abe
Journal:  Prog Lipid Res       Date:  2010-11-11       Impact factor: 16.195

Review 2.  Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

Authors:  Edward A Dennis; Jian Cao; Yuan-Hao Hsu; Victoria Magrioti; George Kokotos
Journal:  Chem Rev       Date:  2011-09-12       Impact factor: 60.622

3.  Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.

Authors:  Kosuke Saito; Keiko Maekawa; Masaki Ishikawa; Yuya Senoo; Masayo Urata; Mayumi Murayama; Noriyuki Nakatsu; Hiroshi Yamada; Yoshiro Saito
Journal:  Toxicol Sci       Date:  2014-06-30       Impact factor: 4.849

4.  A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity.

Authors:  Akira Abe; Piotr W Rzepecki; James A Shayman
Journal:  Anal Biochem       Date:  2012-11-09       Impact factor: 3.365

5.  Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.

Authors:  Scott D Larsen; Michael W Wilson; Akira Abe; Liming Shu; Christopher H George; Paul Kirchhoff; H D Hollis Showalter; Jianming Xiang; Richard F Keep; James A Shayman
Journal:  J Lipid Res       Date:  2011-11-04       Impact factor: 5.922

Review 6.  Lysosomal phospholipase A2.

Authors:  James A Shayman; John J G Tesmer
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2018-08-02       Impact factor: 4.698

7.  Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro.

Authors:  Angelo Y Meliton; Nilda M Muñoz; Lucille N Meliton; David C Binder; Christopher M Osan; Xiangdong Zhu; Steven M Dudek; Alan R Leff
Journal:  J Inflamm (Lond)       Date:  2010-03-18       Impact factor: 4.981

Review 8.  Drug induced phospholipidosis: an acquired lysosomal storage disorder.

Authors:  James A Shayman; Akira Abe
Journal:  Biochim Biophys Acta       Date:  2012-08-30

9.  The role of negatively charged lipids in lysosomal phospholipase A2 function.

Authors:  Akira Abe; James A Shayman
Journal:  J Lipid Res       Date:  2009-03-25       Impact factor: 5.922

10.  Identification of drugs inducing phospholipidosis by novel in vitro data.

Authors:  Markus Muehlbacher; Philipp Tripal; Florian Roas; Johannes Kornhuber
Journal:  ChemMedChem       Date:  2012-09-03       Impact factor: 3.466
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