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Literature DB >> 19353604

Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI.

Shin Mizukami¹, Rika Takikawa, Fuminori Sugihara, Masahiro Shirakawa, Kazuya Kikuchi.

Abstract

Dynamic duo: Magnetic resonance imaging (MRI) can visualize deep regions of living bodies, whereas fluorescence measurement offers excellent sensitivity. These methods thus offer signal enhancement potential for detecting enzyme activities. A dual-mode off/on probe to detect caspase-3 activity by fluorescence and (19)F MRI is presented.

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Year: 2009 PMID： 19353604 DOI： 10.1002/anie.200806328

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

21 in total

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Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI.

Review 1. Multimodality imaging probes: design and challenges.

2. Optical imaging of tumor microenvironment.

Review 3. New frontiers and developing applications in 19F NMR.

4. A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex.

5. Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis.

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