Literature DB >> 19351821

The role of the mouse y chromosome on susceptibility to testicular germ cell tumors.

Philip D Anderson1, Man-Yee Lam, Christophe Poirier, Colin E Bishop, Joseph H Nadeau.   

Abstract

Testicular germ cell tumors (TGCT) are sex limited, occurring only in males with a Y chromosome. Recently, the gr/gr deletion on the human Y chromosome was associated with increased risk of TGCTs. In addition, the presence of Y chromosome sequences is associated with TGCTs in cases of gonadal dysgenesis. TGCTs in strain 129 males recapitulate many aspects of testicular cancer in human infants and can be used to evaluate the role of the Y chromosome in TGCT risk. We used chromosome substitution strains and a sex-reversing mutant to test the role of the Y chromosome on TGCT susceptibility. Our results show that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis.

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Year:  2009        PMID： 19351821      PMCID： PMC3375048          DOI： 10.1158/0008-5472.CAN-08-4881

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  42 in total

1.  Protein structure prediction for the male-specific region of the human Y chromosome.

Authors:  Krzysztof Ginalski; Leszek Rychlewski; David Baker; Nick V Grishin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-24       Impact factor: 11.205

2.  Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain.

Authors:  A Matin; G B Collin; Y Asada; D Varnum; J H Nadeau
Journal:  Nat Genet       Date:  1999-10       Impact factor: 38.330

3.  A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice.

Authors:  Yangjun Qin; Christophe Poirier; Cavatina Truong; Armin Schumacher; Alexander I Agoulnik; Colin E Bishop
Journal:  Hum Mol Genet       Date:  2003-03-01       Impact factor: 6.150

Review 4.  Gonadal function in men with testicular cancer: biological and clinical aspects.

Authors:  P M Petersen; N E Skakkebaek; A Giwercman
Journal:  APMIS       Date:  1998-01       Impact factor: 3.205

5.  Case-control study of whether subfertility in men is familial.

Authors:  R Lilford; A M Jones; D T Bishop; J Thornton; R Mueller
Journal:  BMJ       Date:  1994-09-03

6.  A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice.

Authors:  T Noguchi; M Noguchi
Journal:  J Natl Cancer Inst       Date:  1985-08       Impact factor: 13.506

Review 7.  Genetic predisposition to testicular germ-cell tumours.

Authors:  M F Lutke Holzik; E A Rapley; H J Hoekstra; D T Sleijfer; I M Nolte; R H Sijmons
Journal:  Lancet Oncol       Date:  2004-06       Impact factor: 41.316

8.  Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

Authors:  R Reijo; T Y Lee; P Salo; R Alagappan; L G Brown; M Rosenberg; S Rozen; T Jaffe; D Straus; O Hovatta
Journal:  Nat Genet       Date:  1995-08       Impact factor: 38.330

9.  A physical analysis of the Y chromosome shows no additional deletions, other than Gr/Gr, associated with testicular germ cell tumour.

Authors:  R Linger; D Dudakia; R Huddart; D Easton; D T Bishop; M R Stratton; E A Rapley
Journal:  Br J Cancer       Date:  2007-01-09       Impact factor: 7.640

10.  MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis.

Authors:  Katsuhiko Hayashi; Susana M Chuva de Sousa Lopes; Masahiro Kaneda; Fuchou Tang; Petra Hajkova; Kaiqin Lao; Donal O'Carroll; Partha P Das; Alexander Tarakhovsky; Eric A Miska; M Azim Surani
Journal:  PLoS One       Date:  2008-03-05       Impact factor: 3.240
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  4 in total

1.  Transgenerational genetic effects of the paternal Y chromosome on daughters' phenotypes.

Authors:  Vicki R Nelson; Sabrina H Spiezio; Joseph H Nadeau
Journal:  Epigenomics       Date:  2010-08       Impact factor: 4.778

2.  Mammalian germ cells are determined after PGC colonization of the nascent gonad.

Authors:  Peter K Nicholls; Hubert Schorle; Sahin Naqvi; Yueh-Chiang Hu; Yuting Fan; Michelle A Carmell; Ina Dobrinski; Adrienne L Watson; Daniel F Carlson; Scott C Fahrenkrug; David C Page
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-21       Impact factor: 11.205

3.  Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.

Authors:  Rod T Mitchell; Philippa T K Saunders; Andrew J Childs; Claire Cassidy-Kojima; Richard A Anderson; W Hamish B Wallace; Chris J H Kelnar; Richard M Sharpe
Journal:  Hum Reprod       Date:  2010-08-03       Impact factor: 6.918

Review 4.  Y chromosome is moving out of sex determination shadow.

Authors:  Raheleh Heydari; Zohreh Jangravi; Samaneh Maleknia; Mehrshad Seresht-Ahmadi; Zahra Bahari; Ghasem Hosseini Salekdeh; Anna Meyfour
Journal:  Cell Biosci       Date:  2022-01-04       Impact factor: 7.133
  4 in total

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