AIMS/HYPOTHESIS: We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. METHODS: A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. RESULTS: The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not differ between GDM mothers and controls. In contrast, the low-risk DQB1*0602 allele was less prevalent (OR 0.64, 95% CI = 0.51-0.80, p = 0.0006) in GDM than in control mothers. The difference in DQB1*0602 frequency between GDM mothers and controls remained after multiple logistic regression analysis correcting for maternal age, country of birth, number of pregnancies/siblings and weight gain during pregnancy (OR 0.67, 95% CI 0.51-0.88, p = 0.009). CONCLUSIONS/ INTERPRETATION: The negative association between mothers who have non-autoimmune GDM and HLA-DQ*0602 suggest that this allele may protect not only from type 1 diabetes but also from GDM.
AIMS/HYPOTHESIS: We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. METHODS: A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. RESULTS: The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not differ between GDM mothers and controls. In contrast, the low-risk DQB1*0602 allele was less prevalent (OR 0.64, 95% CI = 0.51-0.80, p = 0.0006) in GDM than in control mothers. The difference in DQB1*0602 frequency between GDM mothers and controls remained after multiple logistic regression analysis correcting for maternal age, country of birth, number of pregnancies/siblings and weight gain during pregnancy (OR 0.67, 95% CI 0.51-0.88, p = 0.009). CONCLUSIONS/ INTERPRETATION: The negative association between mothers who have non-autoimmune GDM and HLA-DQ*0602 suggest that this allele may protect not only from type 1 diabetes but also from GDM.
Authors: H E Larsson; K Lynch; B Lernmark; A Nilsson; G Hansson; P Almgren; A Lernmark; S-A Ivarsson Journal: Diabetologia Date: 2005-07-01 Impact factor: 10.122
Authors: J Graham; I Kockum; C B Sanjeevi; M Landin-Olsson; L Nyström; G Sundkvist; H Arnqvist; G Blohmé; F Lithner; B Littorin; B Scherstén; L Wibell; J Ostman; A Lernmark; N Breslow; G Dahlquist Journal: Eur J Immunogenet Date: 1999 Apr-Jun
Authors: N Shaat; M Ekelund; A Lernmark; S Ivarsson; A Nilsson; R Perfekt; K Berntorp; L Groop Journal: Diabetologia Date: 2004-04-17 Impact factor: 10.122
Authors: P Damm; C Kühl; K Buschard; B K Jakobsen; A Svejgaard; F Sodoyez-Goffaux; M Shattock; G F Bottazzo; L Mølsted-Pedersen Journal: Diabet Med Date: 1994-07 Impact factor: 4.359
Authors: A Papadopoulou; K F Lynch; N Shaat; R Håkansson; S A Ivarsson; K Berntorp; C D Agardh; Å Lernmark Journal: Diabet Med Date: 2011-09 Impact factor: 4.359
Authors: Alexandra M Binder; Jessica LaRocca; Corina Lesseur; Carmen J Marsit; Karin B Michels Journal: Clin Epigenetics Date: 2015-08-05 Impact factor: 6.551
Authors: Adriane F Evangelista; Cristhianna V A Collares; Danilo J Xavier; Claudia Macedo; Fernanda S Manoel-Caetano; Diane M Rassi; Maria C Foss-Freitas; Milton C Foss; Elza T Sakamoto-Hojo; Catherine Nguyen; Denis Puthier; Geraldo A Passos; Eduardo A Donadi Journal: BMC Med Genomics Date: 2014-05-23 Impact factor: 3.063